DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp8b

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_002729572.1	Gene:	Bmp8b / 679119	RGDID:	1591873	Length:	399	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	95/469 - (20%)
Similarity:	168/469 - (35%)	Gaps:	160/469 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 PKELKSGAVRKVNGINGTQMNENALKKSTYP-------IDINHSIDNKTHTGKNGEMSHNDYEYF 584
            |::::. .:|:|.|:.|...:...|..:..|       :::.|::.:.:..|......|......
  Rat    40 PRDMQR-EIREVLGLPGRPRSRAPLATAQQPASAPLFMLNLYHAMTDDSGNGPPQPHLHRADLIM 103

  Fly   585 NDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAE 649
            :..::..||:        ::||           |:.|.:.|..|...|.       ..|.:|.||
  Rat   104 SFVNIVEHDR--------TLGY-----------QEPHWKEFHFDLTQIP-------AGEAVTAAE 142

  Fly   650 EGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGAN 714
                :|.|:                                        .|..|
  Rat   143 ----FRIYK----------------------------------------EPSTH----------- 152

  Fly   715 KPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQ-VDPKNLGWQKFDLTDTIREW-YGHTSHEK 777
            .|:..:.|.:|::     :.|:...::.:|....| :...:.||...|:|.....| ..|.....
  Rat   153 PPNTTLHISMFEV-----VQERSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHNKDLG 212

  Fly   778 LRLLIDCTGCGGRYSLHLFQTSKLRGNSSD--------YLSTNPNRPFLVLHTESSRT------- 827
            |||.::...                |:|.|        ..:....:||:|...::|::
  Rat   213 LRLYVETED----------------GHSLDPGLAGLLGQTAPRSRQPFMVGFFKASQSPVRAPRT 261

  Fly   828 -RRVRRRAV-----------------DCGGALNGQCC-KESFYVSFKALGWDDWIIAPRGYFANY 873
             |.::::.:                 |..|:|:.:.| :...||||:.|||.|.:|||:||.|.|
  Rat   262 ARPLKKKKLNQVNQLPNSNKHLGIFDDGHGSLDREVCRRHELYVSFRDLGWLDSVIAPQGYSAYY 326

  Fly   874 CRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYYG-DDGII 931
            |.|:|.....:... .|.||      ....|::.|:|      ||.|.|.|::||:||. ::.:|
  Rat   327 CAGECIYPLNSCMN-STNHA------TMQALVHLMKPDIVPKVCCVPTKLSAISLLYYDRNNNVI 384

  Fly   932 KRDLPKMVVDECGC 945
            .|....|||..|||
  Rat   385 LRRERNMVVQACGC 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	40/109 (37%)
Bmp8b	XP_002729572.1	TGFb_propeptide	32..248	CDD:279078	48/310 (15%)
Bmp8b	XP_002729572.1	TGF_beta	298..398	CDD:278448	40/106 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810