Protein Alignment Actbeta and BMP8B

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: XP_011540326.2
• Gene: BMP8B / 656
• HGNCID: 1075
• Length: 427
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 100/385 - (25%)
• Similarity: 147/385 - (38%)
• Gaps: 112/385 - (29%)

  Fly   627 DDHENIDHEDFFGNTQEIITFA-----EEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRID 686
            ||.:....|...|....:::|.     :....:::....||.....::|:.: ::.:|:..|
Human    88 DDEDGAPAERRLGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGE-AVTAAEFRI--- 148

  Fly   687 KPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQ-V 750
                      ..:|..||||           ..:.:.:||:     :.|:...::.:|....| :
Human   149 ----------YKVPSIHLLN-----------RTLHVSMFQV-----VQEQSNRESDLFFLDLQTL 187

  Fly   751 DPKNLGWQKFDLTDTIREWYGHTSHEK--LRLLIDC------TGCGGRYSLHLFQTSKLRGNSSD 807
            ...:.||...|:|.....|. ...|:.  |||.::.      ||.|......| |..|||
Human   188 RAGDEGWLVLDVTAASDCWL-LKRHKDLGLRLYVETEDGETWTGWGWTKDSRL-QMWKLR----- 245

  Fly   808 YLSTNP---------------NRPFLVL---HTESS----RT----RRVRRRAV----------- 835
             ||..|               .||.|.|   |..:|    ||    |.:|||..
Human   246 -LSRTPWVLSLHAPGPAQAPAERPLLCLLQGHCPASPSPIRTPRAVRPLRRRQPKKSNELPQANR 309

  Fly   836 ------DCGGALNGQCC-KESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQ-TFH 892
                  |..|:...|.| :...||||:.|||.||:|||:||.|.||.|:|  ||....... |.|
Human   310 LPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC--SFPLDSCMNATNH 372

  Fly   893 AHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYY-GDDGIIKRDLPKMVVDECGC 945
            |..      ..|::.|.|      ||||.|.|:.|::|| ..:.:|.|....|||..|||
Human   373 AIL------QSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	43/108 (40%)
BMP8B	XP_011540326.2	TGFb_propeptide	33..226	CDD:459906	29/168 (17%)
		TGF_beta_BMP8	323..427	CDD:381668	46/112 (41%)