Protein Alignment Actbeta and BMP7

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_001710.1
• Gene: BMP7 / 655
• HGNCID: 1074
• Length: 431
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 125/560 - (22%)
• Similarity: 188/560 - (33%)
• Gaps: 199/560 - (35%)

  Fly   452 RSERDPSHHKY----------RSPF-DFTFNISKNNVYGKVL--RNRSLERIDKKNSFLNGWTEN 503
            ||.|..:.|.:          ||.. ||:.:   |.|:...:  |.||.||.:.:...|:
Human     4 RSLRAAAPHSFVALWAPLFLLRSALADFSLD---NEVHSSFIHRRLRSQERREMQREILS----- 60

  Fly   504 RQLKINSQIASMPIELKSH----HNSSPKEL----KSGAVRKVNGINGTQMNENALKKSTYPIDI 560
                    |..:|...:.|    |||:|..:    .:.||.:..|..|        :..:||...
Human    61 --------ILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGG--------QGFSYPYKA 109

  Fly   561 NHSIDNKTHTGKNGEMSHNDYEYFND-------YSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQ 618
            ..|.......      |..|..:..|       .::..|||..:|                   .
Human   110 VFSTQGPPLA------SLQDSHFLTDADMVMSFVNLVEHDKEFFH-------------------P 149

  Fly   619 KGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHI 683
            :.||..|..|...|..       .|.:| |.|...|:.|....|..:..|:...::    .|.|:
Human   150 RYHHREFRFDLSKIPE-------GEAVT-AAEFRIYKDYIRERFDNETFRISVYQV----LQEHL 202

  Fly   684 RIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASF 748
            ..:.             :..||:::..|.:.:
Human   203 GRES-------------DLFLLDSRTLWASEE--------------------------------- 221

  Fly   749 QVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNP 813
                   ||..||:|.|...|..:..| .|.|.:......|: |::    .||.|....:...|
Human   222 -------GWLVFDITATSNHWVVNPRH-NLGLQLSVETLDGQ-SIN----PKLAGLIGRHGPQN- 272

  Fly   814 NRPFLV-------LHTESSRTRRVRRRAVDCGGALNGQ-------------------CCKESFYV 852
            .:||:|       :|..|.|:...::|:.:.......|                   |.|...||
Human   273 KQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYV 337

  Fly   853 SFKALGWDDWIIAPRGYFANYCRGDCT---GSFRTPDTFQTFHA------HFI--EEYRKMGLMN 906
            ||:.|||.||||||.||.|.||.|:|.   .|:..    .|.||      |||  |...|
Human   338 SFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMN----ATNHAIVQTLVHFINPETVPK----- 393

  Fly   907 GMRPCCAPIKFSSMSLIYYGD-DGIIKRDLPKMVVDECGC 945
               |||||.:.:::|::|:.| ..:|.:....|||..|||
Human   394 ---PCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	44/111 (40%)
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:459906	66/362 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..311		2/19 (11%)
		TGF_beta_BMP7	325..431	CDD:381667	46/118 (39%)