DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and BMP6

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001709.1	Gene:	BMP6 / 654	HGNCID:	1073	Length:	513	Species:	Homo sapiens

Alignment Length:	597	Identity:	132/597 - (22%)
Similarity:	204/597 - (34%)	Gaps:	203/597 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 AFASPGSHLFNGRGGRTDQRSERDPSHHKYRSPFDFTFNISKN-----------NVYGKVLRNRS 486
            |.|:.|..|. |.||...:..:..||.   :|...|.:...|.           :|.|...|.|.
Human    35 AAAAAGGQLL-GDGGSPGRTEQPPPSP---QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRP 95

  Fly   487 LERIDKKNSFLNGWTENRQLKINSQIASMPIELKSHHNSSPKELKS---------GAVRKVNGIN 542
            |..:.:...     ...||.:...|...:|     .....|..|||         .|:...|..:
Human    96 LHGLQQPQP-----PALRQQEEQQQQQQLP-----RGEPPPGRLKSAPLFMLDLYNALSADNDED 150

  Fly   543 GTQMNE----------NALKKSTYPIDINHSIDNKT----HTGKNGE---MSHNDYEYFND---- 586
            |....|          ::.::...|....|.::.|:    .:|..|.   .|..|..:.||
Human   151 GASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMV 215

  Fly   587 ---YSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFA 648
               .::..:||                   |:..::.||:.|..:...|..       .|::|.|
Human   216 MSFVNLVEYDK-------------------EFSPRQRHHKEFKFNLSQIPE-------GEVVTAA 254

  Fly   649 EEGTQYRQYR---ILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRK 710
            |    :|.|:   :..|..|...:...::    .|.|...|.             :..||:|:..
Human   255 E----FRIYKDCVMGSFKNQTFLISIYQV----LQEHQHRDS-------------DLFLLDTRVV 298

  Fly   711 WGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSH 775
            |.:.:                                        ||.:||:|.|...|.....|
Human   299 WASEE----------------------------------------GWLEFDITATSNLWVVTPQH 323

  Fly   776 EK-LRLLIDCTGCGGRYSLHLF-QTSKLRGNSSDYLSTNPNRPFLV-------LHTESSRTRRVR 831
            .. |:|.:..     |..:|:. :.:.|.|....|    ..:||:|       :|..::|:...|
Human   324 NMGLQLSVVT-----RDGVHVHPRAAGLVGRDGPY----DKQPFMVAFFKVSEVHVRTTRSASSR 379

  Fly   832 RR------------------AVDCGGA-LNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGD 877
            ||                  |.|...: |...|.|...||||:.|||.||||||:||.||||.|:
Human   380 RRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGE 444

  Fly   878 CTGSFRTPDTFQTFHAHFIEEYRK-----MGLMNG---MRPCCAPIKFSSMSLIYYGDD-GIIKR 933
            |  ||       ..:||.......     :.|||.   .:|||||.|.:::|::|:.|: .:|.:
Human   445 C--SF-------PLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILK 500

  Fly   934 DLPKMVVDECGC 945
            ....|||..|||
Human   501 KYRNMVVRACGC 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078	19/86 (22%)
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	44/110 (40%)
BMP6	NP_001709.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..66		8/31 (26%)
		TGFb_propeptide	65..362	CDD:279078	68/402 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..131		9/51 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..200		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..398		4/24 (17%)
		TGFB	412..513	CDD:214556	46/110 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810