Protein Alignment Actbeta and BMP5

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_066551.1
• Gene: BMP5 / 653
• HGNCID: 1072
• Length: 454
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 119/534 - (22%)
• Similarity: 185/534 - (34%)
• Gaps: 169/534 - (31%)

  Fly   472 ISKNNVYG----KVLRNRSLERIDKKNSFLNGWTEN-RQLKINSQIASMPIELKSHHNSSPKELK 531
            :..|:|:.    :.|||.....|.::...:.|.... |......|.:|.|:.:...:|:
Human    29 LGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNA------ 87

  Fly   532 SGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNG-EMSHNDYEYFNDYSVQT---- 591
                         ..||...::|.|  .:..|:..:|...:.| ..|.|.|......|..|
Human    88 -------------MTNEENPEESEY--SVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTT 137

  Fly   592 --------HDKNRYHEGRSSIGYQPAI-HNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITF 647
                    ||.|..::....:.:...: .:.::.:|:.|::.|..|...|.|       .|.:|.
Human   138 QSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPH-------GEAVTA 195

  Fly   648 AEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWG 712
            ||       :||.:..:.||
Human   196 AE-------FRIYKDRSNNR--------------------------------------------- 208

  Fly   713 ANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEK 777
              ..:..|||.::|:..  ..|.:..|..::.....|.  .::||..||:|.|...|..:..:..
Human   209 --FENETIKISIYQIIK--EYTNRDADLFLLDTRKAQA--LDVGWLVFDITVTSNHWVINPQNNL 267

  Fly   778 LRLLIDCTGCG-----------GR--------YSLHLFQTSK--LRGNSSDYLSTNPNRPFLVLH 821
            ...|...||.|           ||        :.:..|:.|:  ||...:.....|.||.....|
Human   268 GLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSH 332

  Fly   822 TESSRTRRVRRRAVDCGGALNGQCCKE-SFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTP 885
            .:|||...|.    |...:...|.||: ..||||:.|||.||||||.||.|.||.|:|  ||
Human   333 QDSSRMSSVG----DYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGEC--SF--- 388

  Fly   886 DTFQTFHAHFIEEYRKMGLMNGM------------------RPCCAPIKFSSMSLIYYGD-DGII 931
                ..:||          ||..                  :|||||.|.:::|::|:.| ..:|
Human   389 ----PLNAH----------MNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVI 439

  Fly   932 KRDLPKMVVDECGC 945
            .:....|||..|||
Human   440 LKKYRNMVVRSCGC 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	42/119 (35%)
BMP5	NP_066551.1	TGFb_propeptide	32..304	CDD:459906	61/357 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..343		8/28 (29%)
		TGF_beta_BMP5	342..454	CDD:381665	46/135 (34%)