Protein Alignment Actbeta and BMP4

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_001334841.1
• Gene: BMP4 / 652
• HGNCID: 1071
• Length: 455
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 101/450 - (22%)
• Similarity: 157/450 - (34%)
• Gaps: 156/450 - (34%)

  Fly   569 HTGKNGEMSHNDYEYFNDYSV----------------------QTHDKNRYHEGRSSIGYQPAIH 611
            |.|  |..|...:|...|:..                      ...|..|...|...   :..||
Human    88 HAG--GRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEE---EEQIH 147

  Fly   612 N--IEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKL 674
            :  :||..:..   |.|:...:..||:...|    |....|.:.:|      |......:|..::
Human   148 STGLEYPERPA---SRANTVRSFHHEEHLEN----IPGTSENSAFR------FLFNLSSIPENEV 199

  Fly   675 SIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGID 739
             |.||::.        |:.|:....|:         |  .:..|||.|:.
Human   200 -ISSAELR--------LFREQVDQGPD---------W--ERGFHRINIYE--------------- 229

  Fly   740 KAIIFRASFQVDPKNL---------------GWQKFDLTDTIREW-------YGHTSHEKLRLLI 782
               :.:...:|.|.:|               .|:.||::..:..|       ||        |.|
Human   230 ---VMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYG--------LAI 283

  Fly   783 DCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPN--------RPFLVLHTESSR----TRRVR---- 831
            :.|        ||.||...:|.......:.|.        ||.||......|    |||.|
Human   284 EVT--------HLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRS 340

  Fly   832 -----RRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTF 891
                 :||    ...|..|.:.|.||.|..:||:|||:||.||.|.||.|||  .|...|...:.
Human   341 PKHHSQRA----RKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDC--PFPLADHLNST 399

  Fly   892 HAHFIEEYRKMGLMNGM-----RPCCAPIKFSSMSLIYYGD-DGIIKRDLPKMVVDECGC 945
            :...::.     |:|.:     :.||.|.:.|::|::|..: |.::.::..:|||:.|||
Human   400 NHAIVQT-----LVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	35/105 (33%)
BMP4	NP_001334841.1	TGFb_propeptide	90..322	CDD:459906	55/303 (18%)
		TGF_beta_BMP4_BMP2B	349..455	CDD:381661	37/112 (33%)