Protein Alignment Actbeta and BMP2

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 89/397 - (22%)
• Similarity: 145/397 - (36%)
• Gaps: 126/397 - (31%)

  Fly   593 DKNRYHEGRSSIGYQPAIHNIEYENQKG------HHESFADDHENIDHED---FFGN-----TQE 643
            |..|.|.|:.  |.....|.:|....:.      |||...::......:.   ||.|     |:|
Human    81 DLYRRHSGQP--GSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEE 143

  Fly   644 IITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTK 708
            .||.||                        |.:...|:...:....|.
Human   144 FITSAE------------------------LQVFREQMQDALGNNSSF----------------- 167

  Fly   709 RKWGANKPHHRIKIWVFQLSTSIN----ITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREW 769
                    ||||.|:......:.|    :| :.:|..::.:.:.:       |:.||:|..:..|
Human   168 --------HHRINIYEIIKPATANSKFPVT-RLLDTRLVNQNASR-------WESFDVTPAVMRW 216

  Fly   770 --YGHTSH---EKLRLLIDCTGCGGRY-----SLHLFQTSKLRGNSSDYLSTNPNRPFLV----- 819
              .||.:|   .::..|.:..|...|:     |||           .|..|.:..||.||
Human   217 TAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLH-----------QDEHSWSQIRPLLVTFGHD 270

  Fly   820 -----LHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCT 879
                 ||....|..:.::|.     .|...|.:...||.|..:||:|||:||.||.|.||.|:|
Human   271 GKGHPLHKREKRQAKHKQRK-----RLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGEC- 329

  Fly   880 GSFRTPDTFQTFHAHFIEEYRKMGLMNGM-----RPCCAPIKFSSMSLIYYGD-DGIIKRDLPKM 938
             .|...|...:.:...::.     |:|.:     :.||.|.:.|::|::|..: :.::.::...|
Human   330 -PFPLADHLNSTNHAIVQT-----LVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDM 388

  Fly   939 VVDECGC 945
            ||:.|||
Human   389 VVEGCGC 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	32/105 (30%)
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	34/109 (31%)
		TGFb_propeptide	52..267	CDD:459906	50/255 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121		9/38 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		4/26 (15%)