DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Inhbc

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_072136.1	Gene:	Inhbc / 64549	RGDID:	621194	Length:	351	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	83/333 - (24%)
Similarity:	124/333 - (37%)	Gaps:	109/333 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   643 EIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNT 707
            |||:||:.|........|||...:|.....:                              :|.|
  Rat    97 EIISFADTGLSNINQTRLEFHFSDRTTGGVE------------------------------VLQT 131

  Fly   708 KRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGH 772
            :              ::|.:....|.|:....:.::.|             .:|...|:...|
  Rat   132 R--------------FMFFMQLPPNTTQTMNIRVLVLR-------------PYDTNLTLTSQY-- 167

  Fly   773 TSHEKLRLLIDCTG-------------CG-GRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTE 823
                  .|.:|.:|             |. |..:|.|...|:| .:||..|....:|||:.....
  Rat   168 ------MLQVDASGWYQLLLGPEAQAACSQGHLTLELVPESQL-AHSSLILDGVSHRPFVAAQVR 225

  Fly   824 SSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDC----TGSFRT 884
            .....|||||.::|.| |:..||::.|:|.|:.:||.||||.|.||..|:|.|.|    .|   .
  Rat   226 VEGKHRVRRRGINCQG-LSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAG---M 286

  Fly   885 PDTFQTFHAHFIEEYRKMGLMNGMR-----------PCCAPIKFSSMSLIYYG-DDGIIKRDLPK 937
            |....:||.         .::|.::           .||.|.....:||:||. |..|:|.|:|.
  Rat   287 PGISASFHT---------AVLNLLKANTDAGTARRGSCCVPTSRRPLSLLYYDRDSNIVKTDIPD 342

  Fly   938 MVVDECGC 945
            |||:.|||
  Rat   343 MVVEACGC 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	39/117 (33%)
Inhbc	NP_072136.1	TGF_beta_INHBC_E	246..351	CDD:381676	41/117 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5700
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm45057
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920