DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Gdf9

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_067704.1	Gene:	Gdf9 / 59304	RGDID:	71038	Length:	440	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	78/373 - (20%)
Similarity:	135/373 - (36%)	Gaps:	99/373 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   641 TQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLS--IRSAQIHIRIDKPHSLWIEKAKSLPEKH 703
            |:|.:........|...|:....||..:.||.:::  :....:...:|:..::          :|
  Rat    98 TKEGVPKPSRSHLYNTVRLFSPCAQQEQAPSNQMTGPLPMVDLLFNLDRVTAM----------EH 152

  Fly   704 LLNTKRKWGANKPHHRIKIWVFQLSTS------------INITEKGIDKAIIFRASFQVDPKNLG 756
            ||.:              :.::.|:.|            :.:.|.........||.:....:...
  Rat   153 LLKS--------------VLLYTLNNSAASSSTVTCVCDLVVKEPMSSSKATPRAPYSFTLRKHR 203

  Fly   757 WQKFDLTDTIREWYGHTSHEKLRLLIDCTGC-------GGRYS----------LHLFQTSKLRGN 804
            |.:.|:|..::.... :|...:.|.::.| |       .|.::          |:|..||....:
  Rat   204 WIEMDVTSLLQPLVA-SSERSIHLSVNFT-CTRDQAPENGTFNMPLSVPPSLILYLNDTSTQAYH 266

  Fly   805 SSDYL------STNP------NRPFLVLHTESSRTRRVRR----------RAVDCGGALN----- 842
            |...|      |.:|      .||.....||..|:.|.||          :.:.....|:
  Rat   267 SWQSLQSTQRHSQHPGQDSVTTRPVEEEATEVERSPRHRRGQKTLSSETKKPLTASFNLSEYFRQ 331

  Fly   843 -----GQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFR----TPDTFQTFHAHFIEE 898
                 .:|....|.:||..|.||:||:||..|...||:|||..:.|    :|  ..|...:.|
  Rat   332 FLFPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYGSP--VHTMVQNII-- 392

  Fly   899 YRKMGLMNGMRPCCAPIKFSSMSLIYYGDDG-IIKRDLPKMVVDECGC 945
            |.|:. .:..||.|.|.|:|.:|::....|| |..::...|:...|.|
  Rat   393 YEKLD-PSVPRPSCVPGKYSPLSVLTIEPDGSIAYKEYEDMIATRCTC 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	35/106 (33%)
Gdf9	NP_067704.1	TGF_beta	337..439	CDD:278448	35/106 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810