DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and gdf6a

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001153466.1	Gene:	gdf6a / 566470	ZFINID:	ZDB-GENE-980526-373	Length:	404	Species:	Danio rerio

Alignment Length:	361	Identity:	92/361 - (25%)
Similarity:	142/361 - (39%)	Gaps:	103/361 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   637 FFGNTQE---IITFAEEGTQ-------YRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKP--- 688
            ||.:::.   |.:|.::|..       .||..:.:.|..     |.|..:..|::.|....|
Zfish    94 FFRSSKSANTITSFVDKGKDDLTLSPLRRQTYLFDVSTL-----SDKEELVGAELRIFRKSPGDV 153

  Fly   689 ----------HSLWIEKAKSLPEKHL-LNTKRK--------WGANKPHHRIKIWVFQLSTSINIT 734
                      |.|.....:.|..:.: |...||        ||..|..|:..    ||...:.:|
Zfish   154 QPSPSGVYNLHLLSCRSERPLASRSIDLQDSRKAEWEVLDVWGIFKHRHQEN----QLCLQLKVT 214

  Fly   735 EKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTS 799
                    ..::..::|.|.||:.:          :..|..|: .:|:..|....|.:|......
Zfish   215 --------YGKSDTEIDLKQLGFHR----------HSRTQQER-AILVVYTRSKKRENLFNEMKE 260

  Fly   800 KLRGNSSDYLSTNPNRPFLVLHTESS---RTRRVRRRAVD------CGGALNGQCCKESFYVSFK 855
            |::....|.            ..||:   :.||.||.|::      .|.....:|.|::.:|:||
Zfish   261 KIKSRGDDD------------EEESALQFKARRRRRTALNNRHGKRHGKKSKSRCSKKALHVNFK 313

  Fly   856 ALGWDDWIIAPRGYFANYCRGDCTGSFRT---PDTFQTFHAHFIEEYRKMGLMNGMRP------C 911
            .||||||||||..|.|.:|.|.|....|:   |    |.|| .|:.     |||.|.|      |
Zfish   314 ELGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEP----TNHA-IIQT-----LMNSMDPNSTPPSC 368

  Fly   912 CAPIKFSSMSLIYYGDDG--IIKRDLPKMVVDECGC 945
            |.|.|.|.:|::|. |.|  ::.:....|||::|||
Zfish   369 CVPTKLSPISILYI-DSGNNVVYKQYEDMVVEQCGC 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	44/112 (39%)
gdf6a	NP_001153466.1	TGFb_propeptide	57..245	CDD:279078	33/178 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..304		9/52 (17%)
		TGFB	308..404	CDD:214556	44/107 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810