DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Actbeta and gdf2

DIOPT Version :9

Sequence 1:NP_651942.2 Gene:Actbeta / 43826 FlyBaseID:FBgn0024913 Length:946 Species:Drosophila melanogaster
Sequence 2:NP_001165057.2 Gene:gdf2 / 563287 ZFINID:ZDB-GENE-100107-1 Length:389 Species:Danio rerio


Alignment Length:388 Identity:97/388 - (25%)
Similarity:142/388 - (36%) Gaps:125/388 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   607 QPAIHNIEYENQKGHHESFADDHENIDHEDFFGN--TQEIITFAEEGTQYRQYRILEFSAQNRRV 669
            ||....||..|:      :|.|..:|...|...:  .|::|....:|.: .|:|:|    .|..:
Zfish    77 QPPQFMIELYNR------YASDKNSIPRSDVIRSFVVQDVIYSIRQGNK-TQHRLL----FNVSI 130

  Fly   670 PSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINIT 734
            |:.: .|.|.|:.:     .:||                         ||.|.....|.||||  
Zfish   131 PNHE-EITSVQLRL-----FTLW-------------------------HRHKPACDDLFTSIN-- 162

  Fly   735 EKGIDKAIIFRASFQVDPKNL-------------GWQKFDLTDTIREWYGHTSHEKLRLLIDCTG 786
                    ::...::.:.|.|             .|:.||:|..:|.|     ||..|      |
Zfish   163 --------VYDVEYEQNAKILHLLDGRDVRESINTWEAFDVTGAVRIW-----HESRR------G 208

  Fly   787 CGG-----RYSLHLFQTS-KLRGNSSDYL-------------STNPNRPFLVLHTE--------S 824
            .|.     ::|...|..| .|..|||..:             |....:..||...:        |
Zfish   209 AGEIQVEVQHSCDSFDISLSLEDNSSAVVIVFSDDLGNRKEESMRKVKEMLVREQQQVGNQAPVS 273

  Fly   825 SRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQ 889
            :|.||.:|:      |.|..|.:.|..|:||.:|||.||:||..|.|..|:|.|.... |.|...
Zfish   274 NRHRRRKRK------AKNNYCRRTSLKVNFKDIGWDKWIVAPPEYDAYECKGVCYFPL-TDDVSP 331

  Fly   890 TFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYYGDDGIIKRDL-PKMVVDECGC 945
            :.||..      ..|:|...|      ||.|.|...::::|.....|..|.| .:|.|.:|||
Zfish   332 SRHAVI------QTLVNLSNPKKANMACCVPTKLDPIAVMYQEKGVITVRHLYEEMKVAKCGC 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActbetaNP_651942.2 TGFb_propeptide 370..>509 CDD:279078
TGF_beta 843..945 CDD:278448 35/108 (32%)
gdf2NP_001165057.2 TGFb_propeptide 60..222 CDD:279078 44/207 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..284 5/26 (19%)
TGF_beta 288..388 CDD:278448 35/106 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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