DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and bmp8a

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001038436.1	Gene:	bmp8a / 561963	ZFINID:	ZDB-GENE-030912-13	Length:	433	Species:	Danio rerio

Alignment Length:	275	Identity:	77/275 - (28%)
Similarity:	111/275 - (40%)	Gaps:	73/275 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 WGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNL-GWQKFDLTDTIREWYGH-T 773
            |..|   |.:.|.|:::     :.||...:..:.....|..|... ||..||:|.....|..| .
Zfish   191 WRFN---HTLHISVYEI-----LREKRHREPELVLLDMQSVPAGQEGWLAFDVTSASNRWLLHPR 247

  Fly   774 SHEKLRLLIDC-------TGCGGR--------YSLHLFQTSKL-------------RGNSSDYLS 810
            |:..:||.::.       .|..||        :.:..|:.|:.             |...:.|..
Zfish   248 SNLGIRLYVETEEDHRSWVGLVGRRGPRSKQPFMVTFFRASQAPCRPPRALKHTNQRKKKTKYDL 312

  Fly   811 TNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCR 875
            .:||||.:.....||     .|:|          |.|...||||..|||.||::||.||.|.||.
Zfish   313 PHPNRPGIFDQNHSS-----GRQA----------CKKHELYVSFSDLGWKDWVLAPTGYSAYYCD 362

  Fly   876 GDC---TGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYYGD-DGI 930
            |:|   .||...    .|.||..      ..|::.:||      ||||.|.|.:::::|.| :.:
Zfish   363 GECDYPLGSCMN----ATNHAMI------QLLVHLLRPDEVPKACCAPTKLSPIAVLFYDDNNNV 417

  Fly   931 IKRDLPKMVVDECGC 945
            |.:....|||..|||
Zfish   418 ILKKQRNMVVKNCGC 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	41/111 (37%)
bmp8a	NP_001038436.1	TGFb_propeptide	46..284	CDD:279078	22/100 (22%)
bmp8a	NP_001038436.1	TGFB	332..432	CDD:214556	41/109 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810