DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and gdf9

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001012383.1	Gene:	gdf9 / 497643	ZFINID:	ZDB-GENE-050221-7	Length:	418	Species:	Danio rerio

Alignment Length:	343	Identity:	80/343 - (23%)
Similarity:	130/343 - (37%)	Gaps:	64/343 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 NTQEIITFAEEG-TQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKH 703
            ||..:||..||. .|.|::.:.:.|....||.||:..::|..:: ..|..|.........|..|.
Zfish   102 NTARLITPREECLKQNREFFMQDISYSLNRVRSQEHLLKSVLLY-SFDHNHLSPFSLLCYLDMKE 165

  Fly   704 LLNTKRKWGAN-------------KPHHRIKIWVFQLSTS----------------INIT--EKG 737
            ..::|.:..:|             :.|||   ||....||                ||:|  |..
Zfish   166 QKSSKDQMCSNHLGIQHSVPLLSFRVHHR---WVEVDVTSFLHPLIQAHKKDIHLLINLTCVEDM 227

  Fly   738 IDK--AIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSK 800
            |.:  ..|.::..::.|::.....: |.||....|...|.:...:.:......|:.:|....:.:
Zfish   228 ISRPGGQIHKSPVELTPRSPSLLLY-LNDTSEVAYQRRSTQGRMVDLTSNHWDGKSTLWELTSRR 291

  Fly   801 LRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIA 865
            .||...   |:..:.|.||...|.:                ...|....|.||||.|..|.|||.
Zfish   292 RRGTLK---SSETSMPKLVPMYEFT----------------TDDCDLYDFRVSFKELKLDHWIIE 337

  Fly   866 PRGYFANYCRGDCTGS--FRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMS-LIYYGD 927
            |:.|...||:|.|..:  |.......|...:.|  |.|:. .:..||.|.|.:::.:| |.:..|
Zfish   338 PKKYNPRYCKGSCPRNVGFMYGSPMHTMVQNLI--YEKLD-SSVPRPTCVPSEYNPLSVLTFEND 399

  Fly   928 DGIIKRDLPKMVVDECGC 945
            .....::..:|:..:|.|
Zfish   400 KSYAYKEYEEMIATKCAC 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	31/104 (30%)
gdf9	NP_001012383.1	TGF_beta	317..417	CDD:278448	31/102 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810