Protein Alignment Actbeta and NODAL

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_060525.3
• Gene: NODAL / 4838
• HGNCID: 7865
• Length: 347
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 75/326 - (23%)
• Similarity: 116/326 - (35%)
• Gaps: 113/326 - (34%)

  Fly   671 SQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITE 735
            ||:..:..|::.:::..|..|..|.:.::...|         ..||.                ||
Human    83 SQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFH---------QPKPD----------------TE 122

  Fly   736 KGIDKAIIFRASFQVD---------PKNLGWQKFDLTDTIREWYGHT-SHEKLRLLIDCTGCGGR 790
            :..|..:   ..||:|         ..:||....::|..:.:|..|. :.||
Human   123 QASDSCL---ERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEK------------- 171

  Fly   791 YSLHLFQTSKLRGNSSDYLSTNP-NRPFLVLHTESSRTRRVRRRAVDCGG------------ALN 842
                  |.|::.|.......|.| ....|:|::..|:.:|      ..||            |..
Human   172 ------QMSRVAGECWPRPPTPPATNVLLMLYSNLSQEQR------QLGGSTLLWEAESSWRAQE 224

  Fly   843 GQ--------------------CCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDT 887
            ||                    |.|..|.|.|..:||..|||.|:.|.|..|.|:|...  ..:.
Human   225 GQLSWEWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNP--VGEE 287

  Fly   888 FQ-TFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYYGDDGIIKRDLPK-MVVDECG 944
            |. |.||:.      ..|:...:|      ||||:|...:|::|. |:|.:..|..| |:|:|||
Human   288 FHPTNHAYI------QSLLKRYQPHRVPSTCCAPVKTKPLSMLYV-DNGRVLLDHHKDMIVEECG 345

  Fly   945 C 945
            |
Human   346 C 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	37/107 (35%)
NODAL	NP_060525.3	TGF_beta_NODAL	245..346	CDD:381637	37/109 (34%)