DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and scw

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001286088.1	Gene:	scw / 46000	FlyBaseID:	FBgn0005590	Length:	400	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	95/408 - (23%)
Similarity:	150/408 - (36%)	Gaps:	109/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 HND-----YEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHED- 636
            ||.     .|.:|:.|.....|...|:                     .|:...||...|.:||
  Fly    61 HNSASKFLLEVYNEISEDQEPKEVLHQ---------------------RHKRSLDDDILISNEDR 104

  Fly   637 -FFGNTQEIITFAE--EGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAK- 697
             ...:...|:||:.  :..|......:..:.....||   :.:...|..:||.|..||...:|.
  Fly   105 QEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVP---VDLSLVQAMLRIYKQPSLVDRRANF 166

  Fly   698 --SLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKF 760
              |:..|  |:.::.:.            :::..|:|.|.                 ...||.:|
  Fly   167 TVSVYRK--LDNRQDFS------------YRILGSVNTTS-----------------SQRGWLEF 200

  Fly   761 DLTDTIREWY---GHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNP------NRP 816
            :||||:|.|.   |.....:||:.|      |...|..|....:...:| ..|..|      |.|
  Fly   201 NLTDTLRYWLHNKGLQRRNELRISI------GDSQLSTFAAGLVTPQAS-RTSLEPFIVGYFNGP 258

  Fly   817 FLVLHTESSRTRR--VRRRAVDCGGA-------------LNGQCCKE-SFYVSFKALGWDDWIIA 865
            .|::..:..|.:|  .:|||   ||.             ...|.|:. :|.|.||.|...:|:||
  Fly   259 ELLVKIQKLRFKRDLEKRRA---GGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELHMHNWVIA 320

  Fly   866 PRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGI 930
            |:.:.|.:|.|.|.....|... .|.|| .::....:...:..:|||.|....:::::.|.::.|
  Fly   321 PKKFEAYFCGGGCNFPLGTKMN-ATNHA-IVQTLMHLKQPHLPKPCCVPTVLGAITILRYLNEDI 383

  Fly   931 IKRDL---PKMVVDECGC 945
            |  ||   .|.|..||||
  Fly   384 I--DLTKYQKAVAKECGC 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	32/105 (30%)
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	51/254 (20%)
scw	NP_001286088.1	TGFB	300..400	CDD:214556	33/104 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910