DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and mav

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_524626.1	Gene:	mav / 43804	FlyBaseID:	FBgn0039914	Length:	701	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	149/770 - (19%)
Similarity:	253/770 - (32%)	Gaps:	273/770 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 IWLLIGLVWFEVKLINCNGI----SSS----NYY-------------------ASNLESHK---- 316
            ||.::.|:......::.:||    |||    :||                   |..||:::
  Fly    97 IWFILILLMSTQHQVSGHGIFRQTSSSKAVFSYYQPKENITFTNLQLQNLENEAKRLETNQHPII 161

  Fly   317 --------GCTLCHES----GKPNIYTDKDNPHTDYNIYNKYHSNNNFNKKTNQPHNNIAPSDEV 369
                    |.....||    .:.:||....|.::..|:....:....||||.:....|..|
  Fly   162 RAKSTPKMGLKNVFESFSKQSRDSIYNASSNKYSLINVSQSKNFPQLFNKKLSVQWINTVP---- 222

  Fly   370 RLESIKRQILTKLGLSHKPNVSHPLPKQFIWETIYRVDGGRMIPNNAFGSSGKNLDQKTIKLRAF 434
             ::|.:.:....:||..|   .|..|.:       |||..|:          |:|..|.:.::..
  Fly   223 -IQSRQTRETRDIGLETK---RHSKPSK-------RVDETRL----------KHLVLKGLGIKKL 266

  Fly   435 ASPGSHLFNGRGGRTDQRSERDPSHHKYRSPFDFTFNISKNNVYGKVLR--NRSLERIDKKNSFL 497
                                  |...|        .|||:.....|.:.  :|.....:|.||:.
  Fly   267 ----------------------PDMRK--------VNISQAEYSSKYIEYLSRLRSNQEKGNSYF 301

  Fly   498 N---GWTENRQLKINSQIASMPIELKSHHNSSPKELK-SGAVRKVNGINGTQMNENALKKSTYPI 558
            |   |.:..|.|..      :.|.....::.|.|.|: ..:::|:|     ::|:|..|...|
  Fly   302 NNFMGASFTRDLHF------LSITTNGFNDISNKRLRHRRSLKKIN-----RLNQNPKKHQNY-- 353

  Fly   559 DINHSIDNKTHTGKNGEMSHNDYEYFN---DYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKG 620
                           |::...:.:..|   .:.:.......:|
  Fly   354 ---------------GDLLRGEQDTMNILLHFPLTNAQDANFH---------------------- 381

  Fly   621 HHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVP---SQKLSIRSAQIH 682
                    |:.||.    .|.:.::.::.           ..:...||.|   ..|:|..|...:
  Fly   382 --------HDKIDE----ANVRLMLLYSS-----------SLATNFRRGPGSRKNKISQISGNDN 423

  Fly   683 IRIDKPHSLWIEKAKSLPEKHL------LNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKA 741
            |                 |:|.      ||...|    ....::.:.|:|| .|.|...|...:.
  Fly   424 I-----------------ERHCNFGDVNLNQSNK----NSSQQLTLKVYQL-LSANRRRKITSRK 466

  Fly   742 IIF-RASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGC---GGRYSLHLFQTS--- 799
            |.| ...||  .....|.:||:|..:|.|. :.|||.|.:.|.|..|   |.|. |..|..|
  Fly   467 IEFGNVGFQ--ETRTQWIEFDVTKAVRSWL-NKSHENLGIEIQCDKCKSIGARI-LSDFSPSTPP 527

  Fly   800 KLRGNSSDYLSTNP---------------------------NRPFLVLHTESSR--TRRVRRRAV 835
            :...:|.::|:..|                           ||....:|..|:.  |.|..:...
  Fly   528 RSTASSDEHLNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTN 592

  Fly   836 DCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFI---- 896
            :| ..|:.:||:....|:||::...::|:.|:.:.|.||.|.|      |......|.|.:
  Fly   593 NC-YKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRC------PPRHNPAHHHALLQSL 650

  Fly   897 ---EEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDL---PKMVVDECGC 945
               |::::     ..||||.|.|...:.:::..::...|..:   ..|.|.||.|
  Fly   651 IWQEDHKR-----APRPCCTPSKLEMLEILHVDENHSDKLKISTWSDMQVVECAC 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078	27/143 (19%)
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	27/111 (24%)
mav	NP_524626.1	TGFb_propeptide	<442..506	CDD:279078	20/67 (30%)
mav	NP_524626.1	TGF_beta	599..700	CDD:278448	27/111 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910