DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and gdf11

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_998140.1	Gene:	gdf11 / 406247	ZFINID:	ZDB-GENE-040427-2	Length:	390	Species:	Danio rerio

Alignment Length:	354	Identity:	93/354 - (26%)
Similarity:	140/354 - (39%)	Gaps:	101/354 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 HESFADD----HENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIH 682
            |..|..|    .:.||.:::...|:.:||.|.|                            .:..
Zfish   107 HHDFQGDASSLEDFIDADEYHATTESVITMASE----------------------------PEPL 143

  Fly   683 IRID-KPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVF-----QLSTSI-------NIT 734
            :::| ||...:.:.:..|....:|             :.::||:     |.||..       .||
Zfish   144 VQVDGKPTCCFFKFSPKLMFTKVL-------------KAQLWVYLQPLKQTSTVYLQILRLKPIT 195

  Fly   735 EKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWY--GHTSHEKLRLLIDCTGCGGRYSLHLFQ 797
            |:|.....|.....::|.:...||..|....::.|:  .||:..     ||         ::.:.
Zfish   196 EQGSRHIRIRSLKIELDSQAGHWQSIDFKHVLQNWFKQPHTNWG-----ID---------INAYD 246

  Fly   798 TSKLRGNSSDYLSTNPN----RPFL---VLHTESSRTRRVRRR-AVDCG-GALNGQCCKESFYVS 853
            .|   ||.....|..|.    :|||   :|.|    |:|.||. .:||. .:...:||:....|.
Zfish   247 ES---GNDLAVTSLGPGEEGLQPFLEVKILET----TKRSRRNLGLDCDEHSTESRCCRYPLTVD 304

  Fly   854 FKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTF-HAHFIEEYRKMGLMNGMRPCCAPIKF 917
            |:|.|| ||||||:.|.||||.|.|...|     .|.: |.|.::.....|   ...|||.|.|.
Zfish   305 FEAFGW-DWIIAPKRYKANYCSGQCEYMF-----MQKYPHTHLVQHANPRG---SAGPCCTPTKM 360

  Fly   918 SSMSLIYYGD-DGIIKRDLPKMVVDECGC 945
            |.::::|:.| ..||...:|.||||.|||
Zfish   361 SPINMLYFNDKQQIIHGKIPGMVVDRCGC 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	41/103 (40%)
gdf11	NP_998140.1	TGFb_propeptide	52..268	CDD:279078	40/218 (18%)
gdf11	NP_998140.1	TGFB	296..390	CDD:214556	43/103 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810