DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and GDF6

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001001557.1	Gene:	GDF6 / 392255	HGNCID:	4221	Length:	455	Species:	Homo sapiens

Alignment Length:	279	Identity:	68/279 - (24%)
Similarity:	98/279 - (35%)	Gaps:	109/279 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   750 VDPKN---LGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLST 811
            :||:.   .||:.||:      |.|.......:|.::.....|          :|....::..:.
Human   202 LDPQGAPPAGWEVFDV------WQGLRHQPWKQLCLELRAAWG----------ELDAGEAEARAR 250

  Fly   812 NPNRP---------------------FLVLHTESSRT---------------------------- 827
            .|.:|                     .||:.|.|.|.
Human   251 GPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPP 315

  Fly   828 ---------------RRVRRRA-VDCGGALNG-----QCCKESFYVSFKALGWDDWIIAPRGYFA 871
                           ||.||.| ....|..:|     :|.|:..:|:||.||||||||||..|.|
Human   316 PSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEA 380

  Fly   872 NYCRGDCTGSFRT---PDTFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYY-G 926
            .:|.|.|....|:   |    |.|| .|:.     |||.|.|      ||.|.|.:.:|::|. .
Human   381 YHCEGVCDFPLRSHLEP----TNHA-IIQT-----LMNSMDPGSTPPSCCVPTKLTPISILYIDA 435

  Fly   927 DDGIIKRDLPKMVVDECGC 945
            .:.::.:....|||:.|||
Human   436 GNNVVYKQYEDMVVESCGC 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	42/116 (36%)
GDF6	NP_001001557.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..93
		TGFb_propeptide	79..281	CDD:395559	15/94 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..351		7/50 (14%)
		TGF_beta_GDF5_6_7	354..455	CDD:381644	43/111 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810