DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and tgfb3

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_919367.2	Gene:	tgfb3 / 369195	ZFINID:	ZDB-GENE-030723-4	Length:	410	Species:	Danio rerio

Alignment Length:	403	Identity:	96/403 - (23%)
Similarity:	147/403 - (36%)	Gaps:	109/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 GRSSIGYQP-AIHNIEYENQKG----HHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRI 659
            |.|.:.||. |::|...:...|    .|:|...|:...::            :|:|   ..::.:
Zfish    59 GPSQVPYQVLALYNSTRDLLDGFGKDRHQSCGQDNTETEY------------YAKE---IHKFNM 108

  Fly   660 LEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRK--WGANKPHHRIKI 722
            ::.|.:|..:|.....|.|......:            |:.||:..|..|.  .....|:
Zfish   109 IQGSPENNDLPYCPKGITSKVFRFDV------------SIMEKNASNLFRAEFRALRMPN----- 156

  Fly   723 WVFQLSTSINITEKGIDKAIIFRASFQVDP------KNL------GWQKFDLTDTIREWY-GHTS 774
                ||||  .||:.|:...|.|....:..      ||:      .|..||:|:|:|||. ...:
Zfish   157 ----LSTS--RTEQRIELYQILRPDEHIGKQRYIGRKNVMIGGTDEWVSFDVTETVREWLTNRAT 215

  Fly   775 HEKLRLLIDCTGCGGRYSLHLFQTS-------------KLRGNSSDYLSTNP------------- 813
            :..|.:.:.|. |      |.|:.:             |.||  .|.....|
Zfish   216 NLGLEISVHCP-C------HTFRPNGEIIENVNEALEVKFRG--MDVEDDGPIRSDMGRLKKPKE 271

  Fly   814 -NRPFLVL------HTESSRTRRVRRRAVD---CGGALNGQCCKESFYVSFKA-LGWDDWIIAPR 867
             |.|.|:|      ..:...|.|.|:||:|   |.......||....|:.|:. ||| .||..|:
Zfish   272 QNLPHLILMMLPPHRLDVLPTSRRRKRALDTKYCFSNYEENCCVRKLYIDFRQDLGW-RWIHEPK 335

  Fly   868 GYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIK 932
            ||.||:|.|.|. ..|:.|   |.|:..:..|..:.......|||.|.....::::||.......
Zfish   336 GYHANFCSGPCP-YLRSAD---TTHSSLLSLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV 396

  Fly   933 RDLPKMVVDECGC 945
            ..|..|:|..|.|
Zfish   397 EQLSNMIVKSCKC 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	32/102 (31%)
tgfb3	NP_919367.2	TGFb_propeptide	22..228	CDD:279078	45/213 (21%)
tgfb3	NP_919367.2	TGF_beta	311..409	CDD:278448	32/102 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910