DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and INHBA

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_016867663.1	Gene:	INHBA / 3624	HGNCID:	6066	Length:	548	Species:	Homo sapiens

Alignment Length:	467	Identity:	130/467 - (27%)
Similarity:	188/467 - (40%)	Gaps:	133/467 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 PKELKSGAVRKVNGINGTQMNENALKKS---TYPID---INHSIDNKTHTGKNGEMSHNDYEYFN 585
            ||::.:.....|..:....:|...|||.   |.|:.   :.::| .|.|.||.||
Human   166 PKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAI-RKLHVGKVGE---------- 219

  Fly   586 DYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEE 650
                     |.|.|....||                        ...:..:....|.|||||||.
Human   220 ---------NGYVEIEDDIG------------------------RRAEMNELMEQTSEIITFAES 251

  Fly   651 GTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHS--LWIEKAK-----SLPEKHLLNTK 708
            ||..:                        .:|..|.|..|  ..:|:|:     .:|:
Human   252 GTARK------------------------TLHFEISKEGSDLSVVERAEVWLFLKVPK------- 285

  Fly   709 RKWGANKPHHRIKIWVFQ--------LSTSINITEKGI--DKAIIFRASFQVDPKNLGWQKFDLT 763
                ||:...::.|.:||        |.|.....|.|:  :::.:..:...||.:...|..|.::
Human   286 ----ANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVS 346

  Fly   764 DTIREW--YGHTSHEKLRLLIDCTGC--GGRYSLHLFQTSKLR--------------GNSSDYLS 810
            .:|:..  .|.:|   |.:.|.|..|  .|. ||.|....|.:              |..:|...
Human   347 SSIQRLLDQGKSS---LDVRIACEQCQESGA-SLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEK 407

  Fly   811 TNPNRPFLVLHTESS--RTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANY 873
            ...:||||:|....|  ...|.|||.::|.|.:| .|||:.|:||||.:||:||||||.||.|||
Human   408 EQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVN-ICCKKQFFVSFKDIGWNDWIIAPSGYHANY 471

  Fly   874 CRGDCTGSFR-TPDTFQTFHAHFIEEYRKMG--LMNGMRPCCAPIKFSSMSLIYYGDDG--IIKR 933
            |.|:|..... |..:..:||:..|..||..|  ....::.||.|.|...||::|| |||  |||:
Human   472 CEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYY-DDGQNIIKK 535

  Fly   934 DLPKMVVDECGC 945
            |:..|:|:||||
Human   536 DIQNMIVEECGC 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	50/106 (47%)
INHBA	XP_016867663.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5953
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1653
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4007
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm40920
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4608
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.000