DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and bmp15

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001018320.1	Gene:	bmp15 / 334183	ZFINID:	ZDB-GENE-030131-6115	Length:	384	Species:	Danio rerio

Alignment Length:	246	Identity:	60/246 - (24%)
Similarity:	83/246 - (33%)	Gaps:	98/246 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   757 WQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNR------ 815
            |.:.|:||       |.|..|          .|..|..           :.|..|.|..
Zfish   179 WTETDVTD-------HVSESK----------DGHVSFF-----------ARYWCTKPEHKRSVAH 215

  Fly   816 ------------PFLVLHTESS----------------RTRRVRRRAVDCGGAL----------- 841
                        |.|:|..|.:                ||||.::     .|::
Zfish   216 RKRFPPQHHLRAPLLLLFLEENKHPVEWGKSFPPLSRPRTRRSKK-----SGSIVSDIPNFKQGL 275

  Fly   842 ----NGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTG----SFRTPDTFQTFHA---HF 895
                ...|...|..|.||.||||.|:|||..|...||.|||..    .:.:|:     ||   .|
Zfish   276 NRVTKNNCKLYSSSVDFKDLGWDHWVIAPHKYNPGYCMGDCPRILHYGYNSPN-----HAIMQTF 335

  Fly   896 IEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIK-RDLPKMVVDECGC 945
            |.|   :|:.:...|.|.|.|:..||::..|.:|.|. ::...|:.|.|.|
Zfish   336 ISE---LGVADIPLPSCVPYKYKRMSMLVMGSNGQIDYKEYEDMIADSCTC 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	38/109 (35%)
bmp15	NP_001018320.1	TGF_beta	281..383	CDD:278448	38/109 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910