DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and inhbb

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_571143.2	Gene:	inhbb / 30275	ZFINID:	ZDB-GENE-990415-2	Length:	393	Species:	Danio rerio

Alignment Length:	426	Identity:	115/426 - (26%)
Similarity:	169/426 - (39%)	Gaps:	122/426 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 INGTQMNENALKKSTYPIDINHSID--NKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSS 603
            :|..||.|.  ...|:||.....:.  .|.|.||..|                       :||
Zfish    68 LNRLQMRER--PNITHPIPKAAMVTALRKLHAGKVRE-----------------------DGR-- 105

  Fly   604 IGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRR 668
                     :|..|..||..     |..:..|     |.|||:|||..........|.|...|.
Zfish   106 ---------VEIPNLDGHAA-----HNEVQEE-----TSEIISFAESDDVTPSKSSLYFLISNE- 150

  Fly   669 VPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINI 733
             .:|.|.:..|          :||:                              .|:|..  ..
Zfish   151 -GNQNLYVLQA----------NLWL------------------------------YFKLMP--GT 172

  Fly   734 TEKGIDKAIIFRA-SFQ--------------VDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLID 783
            .|||:.:.:..|. |::              |:.|..||..|.:::.|||........: .|.|.
Zfish   173 LEKGLRRKVTVRVHSYEPGGQNVHWPMMEKRVELKRSGWHTFPVSEAIREMLAKGGRRQ-DLDIH 236

  Fly   784 CTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTR-RVRRRAVDCGGALNGQCCK 847
            |.||.....|.:....          |...:|||||:..:.:..: |:|:|.::|.|...|.||:
Zfish   237 CEGCEAANVLPILVDP----------SDPSHRPFLVVRAQQADGKHRIRKRGLECDGNNGGLCCR 291

  Fly   848 ESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFR-TPDTFQTFHAHFIEEYRKMGLMNG-MRP 910
            :.||:.|:.:||:||||||.||:.|||.|.|..... .|.:..:||...:.:||..|:..| :..
Zfish   292 QQFYIDFRLIGWNDWIIAPAGYYGNYCEGSCPAYMAGVPGSASSFHTAVVNQYRMRGMSPGSVNS 356

  Fly   911 CCAPIKFSSMSLIYYGDD-GIIKRDLPKMVVDECGC 945
            ||.|.|.|:||::|:.|: .|:|||:|.|:|:||||
Zfish   357 CCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	46/104 (44%)
inhbb	NP_571143.2	TGFb_propeptide	54..263	CDD:279078	61/295 (21%)
inhbb	NP_571143.2	TGFB	289..392	CDD:214556	45/102 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5640
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3867
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm24667
orthoMCL	1	0.900	-	-		OOG6_109477
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4608
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900