DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and gdf6b

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_571062.1	Gene:	gdf6b / 30180	ZFINID:	ZDB-GENE-980526-442	Length:	412	Species:	Danio rerio

Alignment Length:	400	Identity:	105/400 - (26%)
Similarity:	151/400 - (37%)	Gaps:	134/400 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   650 EGTQYRQY--RILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIE--KAKSLPEKHLLNT--- 707
            ||.:..:|  .:|..|..:..:.|:: :|:.|      .:||...|.  |..|..||..||.
Zfish    42 EGNRRAKYGKNVLSASLLSGDIQSRR-AIKDA------IEPHDYMISIYKTFSAAEKLGLNASFF 99

  Fly   708 KRKWGAN----------KPHHRIKIW----VFQLST-SINITEKGIDKAII------FRAS---- 747
            :....||          ..|....:|    :|.:|| |.|:...|.:..|.      ||||
Zfish   100 RSSKAANTITSFVDEGQDDHLNSPLWRQKYLFDVSTLSENVEILGAELRIYTKISGSFRASETGP 164

  Fly   748 -----------FQVDPKNLG--------WQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSL 793
                       ..:|.:.|.        |:.||:.:..:| ..|.||            |.|:.|
Zfish   165 VEIQLLSCQSHTVLDSQTLDLEDAHKPKWEVFDVWEIFKE-RQHHSH------------GNRFCL 216

  Fly   794 HLFQT--SKLRGNSSDYLSTNPN-RP-----FLVLHTES-------------------------- 824
            .|..|  :..|.....||..:.: ||     .||:.|.|
Zfish   217 ELRATLDNPEREIDLQYLGFHRHGRPQLKKAILVVFTRSKKRQSLFYEKREKIKLWGLDSIGKER 281

  Fly   825 ---SRTRRVRRRAVD------CGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTG 880
               |:|||.||.|:.      .|.....:|.|:..:|:|:.||||||:|||..|.|.:|.|.|..
Zfish   282 RSHSKTRRSRRTALPNRHGKRHGKKSKSRCSKKPLHVNFRELGWDDWVIAPLDYEAYHCEGMCDF 346

  Fly   881 SFRT---PDTFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYY-GDDGIIKRDL 935
            ..|:   |    |.|| .|:.     |||.|.|      ||.|.|.|.:|::|. ..:.::.:..
Zfish   347 PLRSHLEP----TNHA-IIQT-----LMNSMNPSNMPPSCCVPSKLSPISILYIDAGNNVVYKQY 401

  Fly   936 PKMVVDECGC 945
            ..|||:.|||
Zfish   402 EDMVVESCGC 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	40/111 (36%)
gdf6b	NP_571062.1	TGFb_propeptide	77..252	CDD:279078	43/187 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..311		8/30 (27%)
		TGF_beta	315..411	CDD:278448	38/105 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810