DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Nodal

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001099864.1	Gene:	Nodal / 294503	RGDID:	1305994	Length:	354	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	62/294 - (21%)
Similarity:	111/294 - (37%)	Gaps:	88/294 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 RVPSQKLSIRSAQIH-------IRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVF 725
            ||..:::::..:|:.       :.:.||.|.|::..::| ||.:.:...           |.|..
  Rat   132 RVWMERITVTPSQVTFASDSTVLEVTKPLSKWLKDPRAL-EKQVSSQAG-----------KCWHQ 184

  Fly   726 QLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGR 790
            ..:..:.:|...:   ::..::...:.:.||.... |.:....|..    ::.:|.::.:|.|.|
  Rat   185 SHTQPVPVTSTSV---LMLYSNRPQEQRQLGGATL-LWEAESSWRA----QEGQLSVERSGWGRR 241

  Fly   791 YSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFK 855
            ...|..                |:|        |...|||:                  |.|.|.
  Rat   242 QRRHHL----------------PDR--------SQLCRRVK------------------FQVDFN 264

  Fly   856 ALGWDDWIIAPRGYFANYCRGDC---TGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRP------C 911
            .:||..|||.|:.|.|..|.|:|   .|....|    |.||:.      ..|:...:|      |
  Rat   265 LIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHP----TNHAYI------QSLLKRYQPHRVPSTC 319

  Fly   912 CAPIKFSSMSLIYYGDDGIIKRDLPKMVVDECGC 945
            |||:|...:|::|..:..::......|:|:||||
  Rat   320 CAPVKTKPLSMLYVDNGRVLLEHHKDMIVEECGC 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	32/110 (29%)
Nodal	NP_001099864.1	TGFb_propeptide	33..169	CDD:279078	7/36 (19%)
Nodal	NP_001099864.1	TGFB	254..353	CDD:214556	35/126 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810