DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp2

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_058874.2	Gene:	Bmp2 / 29373	RGDID:	2211	Length:	394	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	90/397 - (22%)
Similarity:	146/397 - (36%)	Gaps:	127/397 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   593 DKNRYHEGRSSIGYQPAIHNIEYENQKG------HHESFADDHENIDHED---FFGN-----TQE 643
            |..|.|.|:.  |.....|.:|....:.      |||...::...:..:.   ||.|     |.|
  Rat    80 DLYRRHSGQP--GAPAPDHRLERAASRANTVRSFHHEEAIEELPEMSGKTSRRFFFNLSSVPTDE 142

  Fly   644 IITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTK 708
            .:|.||                        |.|...|:                          :
  Rat   143 FLTSAE------------------------LQIFREQM--------------------------Q 157

  Fly   709 RKWGANKPHHRIKIWVF----QLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREW 769
            ...|.:...|||.|:..    ..|:...:| :.:|..::.:.:.|       |:.||:|..:..|
  Rat   158 EALGNSSFQHRINIYEIIKPATASSKFPVT-RLLDTRLVTQNTSQ-------WESFDVTPAVMRW 214

  Fly   770 --YGHTSH---EKLRLLIDCTGCGGRY-----SLHLFQTSKLRGNSSDYLSTNPNRPFLV----- 819
              .|||:|   .::..|.:..|...|:     |||           .|..|.:..||.||
  Rat   215 TAQGHTNHGFVVEVAHLEEKPGVSKRHVRISRSLH-----------QDEHSWSQVRPLLVTFGHD 268

  Fly   820 -----LHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCT 879
                 ||....|..:.::|.     .|...|.:...||.|..:||:|||:||.||.|.||.|:|
  Rat   269 GKGHPLHKREKRQAKHKQRK-----RLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGEC- 327

  Fly   880 GSFRTPDTFQTFHAHFIEEYRKMGLMNGM-----RPCCAPIKFSSMSLIYYGD-DGIIKRDLPKM 938
             .|...|...:.:...::.     |:|.:     :.||.|.:.|::|::|..: :.::.::...|
  Rat   328 -PFPLADHLNSTNHAIVQT-----LVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDM 386

  Fly   939 VVDECGC 945
            ||:.|||
  Rat   387 VVEGCGC 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	32/107 (30%)
Bmp2	NP_058874.2	TGFb_propeptide	41..265	CDD:395559	51/255 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..291		4/26 (15%)
		TGF_beta_BMP2	292..394	CDD:381660	34/109 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810