Protein Alignment Actbeta and Inhba

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_058824.1
• Gene: Inhba / 29200
• RGDID: 62074
• Length: 424
• Species: Rattus norvegicus
• Alignment Length: 479
• Identity: 132/479 - (27%)
• Similarity: 194/479 - (40%)
• Gaps: 140/479 - (29%)

  Fly   512 IASMPIELKSHHNSSPKELKSGAVRKVNGINGTQMNENALKKS---TYPID---INHSIDNKTHT 570
            :|::|   |...||.|:.::  ||:|      ..:|...|||.   |.|:.   :.::| .|.|.
  Rat    40 LATLP---KDGPNSQPEMVE--AVKK------HILNMLHLKKRPDVTQPVPKAALLNAI-RKLHV 92

  Fly   571 GKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHE 635
            ||.||                   |.|.|....||                        ...:..
  Rat    93 GKVGE-------------------NGYVEIEDDIG------------------------RRAEMN 114

  Fly   636 DFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHS--LWIEKAK- 697
            :....|.|||||||.||..:                        .:|..|.|..|  ..:|:|:
  Rat   115 ELMEQTSEIITFAESGTARK------------------------TLHFEISKEGSDLSVVERAEV 155

  Fly   698 ----SLPEKHLLNTKRKWGANKPHHRIKIWVFQ--------LSTSINITEKGI--DKAIIFRASF 748
                .:|:           ||:...::.|.:||        |.......|.|:  :::.:..:..
  Rat   156 WLFLKVPK-----------ANRTRTKVTIRLFQQQKHPQGSLDMGDEAEEMGLKGERSELLLSEK 209

  Fly   749 QVDPKNLGWQKFDLTDTIREW--YGHTSHEKLRLLIDCTGC----------GGRYSLHLFQTSKL 801
            .||.:...|..|.::.:|:..  .|.:|   |.:.|.|..|          |.:....:....|.
  Rat   210 VVDARKSTWHIFPVSSSIQRLLDQGKSS---LDVRIACEQCQESGASLVLLGKKKKKEVDGDGKK 271

  Fly   802 RGNSSDYL---STNPNRPFLVLHTESS--RTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDD 861
            :..|...|   ....:||||:|....|  ...|.|||.::|.|.:| .|||:.|:||||.:||:|
  Rat   272 KDGSDGGLEEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVN-ICCKKQFFVSFKDIGWND 335

  Fly   862 WIIAPRGYFANYCRGDCTGSFR-TPDTFQTFHAHFIEEYRKMG--LMNGMRPCCAPIKFSSMSLI 923
            |||||.||.||||.|:|..... |..:..:||:..|..||..|  ....::.||.|.|...||::
  Rat   336 WIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSML 400

  Fly   924 YYGDDG--IIKRDLPKMVVDECGC 945
            || |||  |||:|:..|:|:||||
  Rat   401 YY-DDGQNIIKKDIQNMIVEECGC 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	50/104 (48%)
Inhba	NP_058824.1	TGFb_propeptide	56..291	CDD:480997	63/324 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..306		10/41 (24%)
		TGF_beta_INHBA	317..424	CDD:381674	53/109 (49%)