DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Inhba

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_058824.1	Gene:	Inhba / 29200	RGDID:	62074	Length:	424	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	132/479 - (27%)
Similarity:	194/479 - (40%)	Gaps:	140/479 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 IASMPIELKSHHNSSPKELKSGAVRKVNGINGTQMNENALKKS---TYPID---INHSIDNKTHT 570
            :|::|   |...||.|:.::  ||:|      ..:|...|||.   |.|:.   :.::| .|.|.
  Rat    40 LATLP---KDGPNSQPEMVE--AVKK------HILNMLHLKKRPDVTQPVPKAALLNAI-RKLHV 92

  Fly   571 GKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHE 635
            ||.||                   |.|.|....||                        ...:..
  Rat    93 GKVGE-------------------NGYVEIEDDIG------------------------RRAEMN 114

  Fly   636 DFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHS--LWIEKAK- 697
            :....|.|||||||.||..:                        .:|..|.|..|  ..:|:|:
  Rat   115 ELMEQTSEIITFAESGTARK------------------------TLHFEISKEGSDLSVVERAEV 155

  Fly   698 ----SLPEKHLLNTKRKWGANKPHHRIKIWVFQ--------LSTSINITEKGI--DKAIIFRASF 748
                .:|:           ||:...::.|.:||        |.......|.|:  :::.:..:..
  Rat   156 WLFLKVPK-----------ANRTRTKVTIRLFQQQKHPQGSLDMGDEAEEMGLKGERSELLLSEK 209

  Fly   749 QVDPKNLGWQKFDLTDTIREW--YGHTSHEKLRLLIDCTGC----------GGRYSLHLFQTSKL 801
            .||.:...|..|.::.:|:..  .|.:|   |.:.|.|..|          |.:....:....|.
  Rat   210 VVDARKSTWHIFPVSSSIQRLLDQGKSS---LDVRIACEQCQESGASLVLLGKKKKKEVDGDGKK 271

  Fly   802 RGNSSDYL---STNPNRPFLVLHTESS--RTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDD 861
            :..|...|   ....:||||:|....|  ...|.|||.::|.|.:| .|||:.|:||||.:||:|
  Rat   272 KDGSDGGLEEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVN-ICCKKQFFVSFKDIGWND 335

  Fly   862 WIIAPRGYFANYCRGDCTGSFR-TPDTFQTFHAHFIEEYRKMG--LMNGMRPCCAPIKFSSMSLI 923
            |||||.||.||||.|:|..... |..:..:||:..|..||..|  ....::.||.|.|...||::
  Rat   336 WIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSML 400

  Fly   924 YYGDDG--IIKRDLPKMVVDECGC 945
            || |||  |||:|:..|:|:||||
  Rat   401 YY-DDGQNIIKKDIQNMIVEECGC 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	50/106 (47%)
Inhba	NP_058824.1	TGFb_propeptide	56..236	CDD:413528	52/266 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..306		10/41 (24%)
		TGF_beta_INHBA	317..424	CDD:381674	53/109 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5700
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1653
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3898
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm45057
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970