DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Mstn

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_062024.1	Gene:	Mstn / 29152	RGDID:	3115	Length:	376	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	99/427 - (23%)
Similarity:	152/427 - (35%)	Gaps:	110/427 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 PIDINHSIDNKTHTGKNGEMS------HNDYEYFNDYSVQTHDKNRYHEG--------RSSIGYQ 607
            |:|:|...:.:.:..|.|..:      :..|.......:|...|.|....        |..:...
  Rat    21 PVDLNEDSEREANVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRA 85

  Fly   608 PAIHNI--EYENQKGHHESFADDHE--NIDHEDFFGNTQEIITFAEEGTQYRQYR------ILEF 662
            |.:..:  :|:.|:       ||..  :::.:|:...|:.|||...|.....|..      ..:|
  Rat    86 PPLRELIDQYDVQR-------DDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKF 143

  Fly   663 SAQ---NRRVPSQKLSIRSAQIHIRIDKPHSLWIE-KAKSLPEKHLLNTKRKWGANKPHHRIKIW 723
            |::   |:.|.:|                  |||. :|...|..
  Rat   144 SSKIQYNKVVKAQ------------------LWIYLRAVKTPTT--------------------- 169

  Fly   724 VF-QLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGC 787
            || |:...|...:.|.....|......:.|....||..|:...::.|.....          :..
  Rat   170 VFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPE----------SNL 224

  Fly   788 GGRYSLHLFQTSKLRGNSSDYLSTNPN------RPFLVLHTESSRTRRVRRRAVDCG-GALNGQC 845
            |       .:...|..|..|...|.|.      .|||.:....:..|..|...:||. .:...:|
  Rat   225 G-------IEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRC 282

  Fly   846 CKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTF-HAHFIEEYRKMGLMNGMR 909
            |:....|.|:|.|| ||||||:.|.||||.|:|...|     .|.: |.|.:.:....|   ...
  Rat   283 CRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVF-----LQKYPHTHLVHQANPRG---SAG 338

  Fly   910 PCCAPIKFSSMSLIYY-GDDGIIKRDLPKMVVDECGC 945
            |||.|.|.|.::::|: |.:.||...:|.||||.|||
  Rat   339 PCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	41/103 (40%)
Mstn	NP_062024.1	TGFb_propeptide	37..250	CDD:413528	45/275 (16%)
Mstn	NP_062024.1	TGF_beta_GDF8	269..376	CDD:381658	45/116 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810