Protein Alignment Actbeta and Gdf2

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_001099566.1
• Gene: Gdf2 / 290921
• RGDID: 1586196
• Length: 430
• Species: Rattus norvegicus
• Alignment Length: 489
• Identity: 105/489 - (21%)
• Similarity: 179/489 - (36%)
• Gaps: 146/489 - (29%)

  Fly   519 LKSHHNSSPKELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEY 583
            |:|...:||    .|..|...|::|::  |..:      .|:...::|         |..:....
  Rat    25 LQSWGQASP----GGNARSSLGLSGSR--EEGV------FDLKMFLEN---------MKVDFLRS 68

  Fly   584 FNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFA 648
            .|...:.:.||.|         .:|..:.|:..|:....:| :....||...  |.....|.|.|
  Rat    69 LNLSGIPSQDKTR---------AEPPQYMIDLYNRYTTDKS-STPASNIVRS--FSVEDAISTAA 121

  Fly   649 EEGTQYRQYRILEFSAQNRRVPSQKLSIR-------SAQIHIRIDKPHSLWIEKAKSLPEKHLLN 706
            .|...:::: ||.|   |..:|..:...|       |.|.|  :|..|.|    ..::....:|:
  Rat   122 TEDFPFQKH-ILIF---NISIPRHEQITRAELRLYVSCQNH--VDSTHGL----EGNMVVYDVLD 176

  Fly   707 TKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWY- 770
            ....|.                     :..|....::.:     |.::.||:..:::..::.|.
  Rat   177 VDETWD---------------------SASGTKTFLVSQ-----DIQDEGWETLEVSSAVKRWVR 215

  Fly   771 --GHTSHEKLRLLID--CTGCG--------GRYSLHLF----------------QTSKLRGNSSD 807
              ..|:..||.:.:.  ..||.        |..:|..|                :..::.|:..:
  Rat   216 ADSTTNKNKLEVTVQRHREGCSTLDISVPPGSQNLPFFVVFSNDRSNGTKETRLELKEMIGHEQE 280

  Fly   808 --YLSTNPNRPFLVLHTESSRTR----RV------------RRRAVDCGGALNGQCCKESFYVSF 854
              .:.|:.|     .:.|:..:|    |:            |:|:.   ||.:..|.|.|..|:|
  Rat   281 TVLVKTSKN-----AYQEAGESREEEERIDGYTAVGPLLARRKRST---GAASSHCQKTSLRVNF 337

  Fly   855 KALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHA------HFIEEYRKMGLMNGMRPCCA 913
            :.:|||.|||||:.|.|..|:|.|.... ..|...|.||      | ::...|:|     :.||.
  Rat   338 EDIGWDSWIIAPKEYDAYECKGGCFFPL-ADDVTPTKHAIVQTLVH-LKFPTKVG-----KACCV 395

  Fly   914 PIKFSSMSLIYYGDDGI--IKRDLPKMVVDECGC 945
            |.|.|.:|::|..|.|:  :|.....|.|.||||
  Rat   396 PTKLSPISILYKDDMGVPTLKYHYEGMSVAECGC 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	39/107 (36%)
Gdf2	NP_001099566.1	TGFb_propeptide	69..215	CDD:480997	34/193 (18%)
		TGF_beta_BMP9	326..430	CDD:381670	41/111 (37%)