DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and tig-3

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_497318.2	Gene:	tig-3 / 266879	WormBaseID:	WBGene00021594	Length:	251	Species:	Caenorhabditis elegans

Alignment Length:	280	Identity:	67/280 - (23%)
Similarity:	102/280 - (36%)	Gaps:	79/280 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   701 EKHLLNTKRK-WGANKPHHRIKIWVFQLS-TSINITEKGIDKAIIFRASFQVDPKN--------- 754
            :|..|...|| |....|...:|. .||.| .|||..        |..||..:|||:
Worm    15 DKITLEPNRKSWTCLTPESLVKD-CFQYSINSINHE--------ILSASLIIDPKDTNISIVVYE 70

  Fly   755 -------------------LGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSK 800
                               |....||::....:|....|.:|: :.|:.|....:..:
Worm    71 VDELFGELQYVDRFEIRETLDKYHFDISHLFHKWMKQKSSDKM-IKIEITNSNTQNVI------- 127

  Fly   801 LRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIA 865
               |:...|...||...:|....:     |.....||.|     ||...|||:|..:||:|||::
Worm   128 ---NALSVLRNAPNFDVMVFQPNT-----VTAGTSDCVG-----CCVIPFYVNFTEIGWNDWILS 179

  Fly   866 PRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGI 930
            |.|::||.|          .||..:..:..:.::.|..:.:...|.|||..:.|:.:|.    .:
Worm   180 PPGFYANVC----------SDTVCSTESDEVYQFMKAAISDLPEPKCAPNYYGSVDMIV----AL 230

  Fly   931 IKRDLPKMVVD-----ECGC 945
            ..||:.|..|.     .|.|
Worm   231 SPRDIRKTRVHGLRALSCSC 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	30/106 (28%)
tig-3	NP_497318.2	TGF_beta_INHB	159..250	CDD:381630	30/104 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6711
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760