DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp4

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_036959.2	Gene:	Bmp4 / 25296	RGDID:	2213	Length:	408	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	92/401 - (22%)
Similarity:	150/401 - (37%)	Gaps:	111/401 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 EYFND-YSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEII 645
            :|..| |.:|:.::....:.:.:        .:||..:..   |.|:...:..||:...|    |
  Rat    81 DYMRDLYRLQSGEEEEEEQSQGT--------GLEYPERPA---SRANTVRSFHHEEHLEN----I 130

  Fly   646 TFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKP---HSLWIEKAKSLPEK----H 703
            ....|.:.:|.:..|....:|..:.|.:|.:...|:....|..   |.:.|.:....|.:    |
  Rat   131 PGTSESSAFRFFFNLSSIPENEVISSAELRLFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGH 195

  Fly   704 LLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIRE 768
            |:.  |.......||             |:|.                     |:.||::..:..
  Rat   196 LIT--RLLDTRLVHH-------------NVTR---------------------WETFDVSPAVLR 224

  Fly   769 W-------YGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPN--------RPFL 818
            |       ||        |.|:.|        ||.||...:|.......:.|.        ||.|
  Rat   225 WTREKQPNYG--------LAIEVT--------HLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLL 273

  Fly   819 VLHTESSR----TRRVRRRA----VDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCR 875
            |......|    |||..:|:    .......|..|.:.|.||.|..:||:|||:||.||.|.||.
  Rat   274 VTFGHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCH 338

  Fly   876 GDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGM-----RPCCAPIKFSSMSLIYYGD-DGIIKRD 934
            |||  .|...|...:.:...::.     |:|.:     :.||.|.:.|::|::|..: |.::.::
  Rat   339 GDC--PFPLADHLNSTNHAIVQT-----LVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKN 396

  Fly   935 LPKMVVDECGC 945
            ..:|||:.|||
  Rat   397 YQEMVVEGCGC 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	35/107 (33%)
Bmp4	NP_036959.2	TGFb_propeptide	41..276	CDD:395559	49/261 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..113		2/32 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..307		6/25 (24%)
		TGF_beta_BMP4_BMP2B	302..408	CDD:381661	38/113 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810