DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Gdf5

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_003749648.1	Gene:	Gdf5 / 252835	RGDID:	620102	Length:	495	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	107/456 - (23%)
Similarity:	159/456 - (34%)	Gaps:	114/456 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 SPKELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSH-------NDYEY 583
            :||...||.  |.:...|:..:...|||:..|             |...|...       ..:||
  Rat   117 TPKGQLSGG--KASAKAGSAPSSFLLKKTREP-------------GTPREPKEPFRPPPITPHEY 166

  Fly   584 FNDYSVQTHDKNRYHEGRSSIGYQPAIHN-IEYENQKGHHESFADDHENIDHEDFFGNTQEIITF 647
            .........|.:| ..|.||:..:..:.| |.....||.     ||...:..:..:  ..:|...
  Rat   167 MLSLYRTLSDADR-KGGNSSVKLEAGLANTITSFIDKGQ-----DDRGPVVRKQRY--VFDISAL 223

  Fly   648 AEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKH----LLNTK 708
            .::|....:.|||.....:...|:...|.|.||:             |..|.|...    ||:.:
  Rat   224 EKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQL-------------KLSSCPSGRQPAALLDVR 275

  Fly   709 RKWGANKPHHRI-KIWVF--------QLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTD 764
            ...|.:.....: .||..        ||...:...|:|       ||   ||.:.||:::
  Rat   276 SVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERG-------RA---VDLRGLGFER----- 325

  Fly   765 TIREWYGHTSHEKLRLLIDCTGCGGRYSLH--LFQTSKLRGNSSD---YLSTNPNRPFLVLHTES 824
                 .....|||...|:     .||....  .|...|.|....|   |       .:|......
  Rat   326 -----AARQVHEKALFLV-----FGRTKKRDLFFNEIKARSGQDDKTVY-------EYLFSQRRK 373

  Fly   825 SRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRT---PD 886
            .|.....|:.......|..:|.:::.:|:||.:|||||||||..|.|.:|.|.|....|:   |
  Rat   374 RRAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEP- 437

  Fly   887 TFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSLIYYGD-DGIIKRDLPKMVVDECG 944
               |.||..      ..|||.|.|      ||.|.:.|.:|:::... :.::.:....|||:.||
  Rat   438 ---TNHAVI------QTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCG 493

  Fly   945 C 945
            |
  Rat   494 C 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	37/111 (33%)
Gdf5	XP_003749648.1	TGFb_propeptide	147..338	CDD:413528	46/231 (20%)
Gdf5	XP_003749648.1	TGF_beta_GDF5	393..495	CDD:381669	39/112 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810