DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and Gdf6

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001013056.1	Gene:	Gdf6 / 252834	RGDID:	620104	Length:	452	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	104/479 - (21%)
Similarity:	170/479 - (35%)	Gaps:	146/479 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 STYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGR-----SSIGYQPAIHN- 612
            |:..:|....::|:    |.|:|.....|.....:.:.| :.|.:|.|     .|:|.:|....
  Rat    32 SSTELDSTKDVENR----KGGKMQRTPQESAEGRTPKEH-RPRPNELRRRLPGQSLGQEPPGRGP 91

  Fly   613 --IEYENQKGHHESFADDHENIDHEDFFGNTQE---IITFAEEG------TQYRQYRILEFSAQN 666
              :.:|.....:.:::...:...:..||.:::.   |.:|.:.|      |..|:.:.| |....
  Rat    92 RVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYL-FDVST 155

  Fly   667 RRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSI 731
            .   |.|..:..|::.:....|.:.|..:.:.|   ||                  .:|...:.:
  Rat   156 L---SDKEELVGAELRLYRQAPPTPWGPQTRPL---HL------------------QLFPCLSPL 196

  Fly   732 NITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLL---IDCTGCGGRYSL 793
            .:..:.:|..         .|...||:.||:...:|.........:||.:   :|....|.|
  Rat   197 LLDSRTLDPQ---------GPTEAGWEVFDVWQVLRPQPWKQLCLELRAVWGELDARDSGAR--- 249

  Fly   794 HLFQTSKLRGNSS----DYLSTN--------PNRPFLVLHTESSRT------------------- 827
                   .||...    |..|..        ..|..||:.|.|.|.
  Rat   250 -------PRGPQQSPPLDLRSLGFGRRVRPPQERALLVVFTRSQRKNLFTEMHEQLGSAEAAGAE 307

  Fly   828 --------------------RRVRRRAVDC-GGALNG-----QCCKESFYVSFKALGWDDWIIAP 866
                                ||.||.|:.. .|..:|     :|.::..:|:||.||||||||||
  Rat   308 GSWPAPSGAPDAGSWLPSPGRRRRRTALSSRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAP 372

  Fly   867 RGYFANYCRGDCTGSFRT---PDTFQTFHAHFIEEYRKMGLMNGMRP------CCAPIKFSSMSL 922
            ..|.|.:|.|.|....|:   |    |.|| .|:.     |||.|.|      ||.|.|.:.:|:
  Rat   373 LEYEAYHCEGVCDFPLRSHLEP----TNHA-IIQT-----LMNSMDPGSTPPSCCVPTKLTPISI 427

  Fly   923 IYY-GDDGIIKRDLPKMVVDECGC 945
            :|. ..:.::.:....|||:.|||
  Rat   428 LYIDAGNNVVYKQYEDMVVESCGC 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	41/116 (35%)
Gdf6	NP_001013056.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..93		14/65 (22%)
		TGFb_propeptide	66..282	CDD:279078	45/260 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..348		7/46 (15%)
		TGF_beta	350..451	CDD:278448	40/110 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810