DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and Inhbb

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_542949.1	Gene:	Inhbb / 25196	RGDID:	2913	Length:	411	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	115/403 - (28%)
Similarity:	174/403 - (43%)	Gaps:	105/403 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 DINHSID--------NKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEY 615
            :|.|::.        .|.|.||..|                       :||           :|.
  Rat    97 NITHAVPKAAMVTALRKLHAGKVRE-----------------------DGR-----------VEI 127

  Fly   616 ENQKGHHESFADDHENIDHEDFFGNTQEIITFAE-EGTQYRQYRILEFSAQNRRVPSQKLSIRSA 679
            .:..||....||..|.:         .|||:||| :|....:.|:..|.:..   .:|.|.:..|
  Rat   128 PHLDGHASPGADGQERV---------SEIISFAETDGLASSRVRLYFFVSNE---GNQNLFVVQA 180

  Fly   680 QIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQ---LSTSINITEKGIDKA 741
                      |||: ..|.||......::||       .|:|:: ||   .....|:.||
  Rat   181 ----------SLWL-YLKLLPYVLEKGSRRK-------VRVKVY-FQEQGHGDRWNVVEK----- 221

  Fly   742 IIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSS 806
                   :||.|..||..|.:|:.|:..: .....:|.|.:.|..|.....:.:|...   |..|
  Rat   222 -------KVDLKRSGWHTFPITEAIQALF-ERGERRLNLDVQCDSCQELAVVPVFVDP---GEES 275

  Fly   807 DYLSTNPNRPFLVLHTESSRTR-RVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYF 870
                   :|||:|:......:| |:|:|.::|.|. ...||::.|::.|:.:||:||||||.||:
  Rat   276 -------HRPFVVVQARLGDSRHRIRKRGLECDGR-TSLCCRQQFFIDFRLIGWNDWIIAPTGYY 332

  Fly   871 ANYCRGDCTGSFR-TPDTFQTFHAHFIEEYRKMGLMNG-MRPCCAPIKFSSMSLIYYGDD-GIIK 932
            .|||.|.|..... .|.:..:||...:.:||..||..| :..||.|.|.||||::|:.|: .|:|
  Rat   333 GNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDEYNIVK 397

  Fly   933 RDLPKMVVDECGC 945
            ||:|.|:|:||||
  Rat   398 RDVPNMIVEECGC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	46/104 (44%)
Inhbb	NP_542949.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..69
		TGFb_propeptide	73..282	CDD:413528	60/272 (22%)
		TGF_beta_INHBB	305..411	CDD:381675	48/106 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3898
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm45057
orthoMCL	1	0.900	-	-		OOG6_109477
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970