DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Inha

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_036722.1	Gene:	Inha / 24504	RGDID:	2912	Length:	366	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	83/402 - (20%)
Similarity:	127/402 - (31%)	Gaps:	149/402 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 GYQPAIHNIEYENQKG--HHESFADDHENIDHEDFF--------------GNTQEIITFAEEGTQ 653
            |..|.|..:...:..|  .|.:...:.|::.....|              |..||    .|||..
  Rat    52 GGGPGIRRLPRRHALGGFMHRTSEPEEEDVSQAILFPATGATCEDQAAAGGLAQE----PEEGLF 112

  Fly   654 YRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKW---GANK 715
            ...:|           |||         |||                 .|.:.:.:.|   |.::
  Rat   113 TYVFR-----------PSQ---------HIR-----------------SHQVTSAQLWFHTGLDR 140

  Fly   716 PHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLG-----WQKFDLTDTIREWYGHTSH 775
                      :.:.:.|.:...:|..::........|.:||     |....|..:.   :...:|
  Rat   141 ----------KSTAASNSSRPLLDLLVLSSGGPMAVPVSLGQSPPRWAVLHLAASA---FPLLTH 192

  Fly   776 EKLRLLIDC--TGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTES---SRTRRVRRRAV 835
            ..|.||:.|  ..|.||                     ....||||.||.:   |...|.||.|.
  Rat   193 PILVLLLRCPLCSCSGR---------------------PETTPFLVAHTRARAPSAGERARRSAP 236

  Fly   836 D-----CGGAL------------NGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDC----- 878
            .     ...||            :..|.:.:..:||:.||||.||:.|..:..:||.|.|
  Rat   237 SMPWPWSPAALRLLQRPPEEPSAHAFCHRAALNISFQELGWDRWIVHPPSFIFHYCHGSCGMPTS 301

  Fly   879 ------TGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSL-IYYGDDG--IIKRD 934
                  .|:..||             .:.:.|:.|.:||||.:..|..|| :....||  ..|.:
  Rat   302 DLPLPVPGAPPTP-------------AQPLFLVPGAKPCCAALPGSMRSLRVRTTSDGGYSFKYE 353

  Fly   935 L-PKMVVDECGC 945
            : |.::...|.|
  Rat   354 MVPNLITQHCAC 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	31/116 (27%)
Inha	NP_036722.1	TGFB	263..366	CDD:214556	32/116 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000