DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Gdf6

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_038554.1	Gene:	Gdf6 / 242316	MGIID:	95689	Length:	454	Species:	Mus musculus

Alignment Length:	495	Identity:	100/495 - (20%)
Similarity:	172/495 - (34%)	Gaps:	160/495 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 QMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFN-----DYSVQTHDKNR----YHEG 600
            |.:.::...|:..:|....:.|:    |.|:|.....|...     ::.::..|..|    .|:|
Mouse    25 QASISSSSSSSTELDSTKDVGNR----KEGKMQRTPQESAEGRTPPEHGLRQKDLRRRPPGQHQG 85

  Fly   601 RSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQE---IITFAEEG------TQYRQ 656
            :...|  ..:..:.:|.....:::::...:...:..||.:::.   |.:|.:.|      |..|:
Mouse    86 QEPPG--RGLRVVPHEYMLSIYKTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRR 148

  Fly   657 YRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIK 721
            .:.| |.....   |.|..:..|::.:....|.:.|     .||.             :|.|
Mouse   149 QKYL-FDVSTL---SDKEELVGAELRLYRQAPPTPW-----GLPA-------------RPLH--- 188

  Fly   722 IWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTG 786
            :.:|...:.:.:..:.:|..         .|...||:.||:      |.|.......:|.::...
Mouse   189 LQLFPCLSPLLLDARTLDPQ---------GPTQAGWEVFDV------WQGLRPQPWKQLCLELRA 238

  Fly   787 CGGRYSLHLFQTSKLRGNSSDYLSTNPNRP---------------------FLVLHTESSRT--- 827
            ..|          :|....:...:..|.:|                     .||:.|.|.|.
Mouse   239 AWG----------ELDAGDTGARARGPQQPPPLDLRSLGFGRRVRPPQERALLVVFTRSQRKNLF 293

  Fly   828 ------------------------------------RRVRRRA-VDCGGALNG-----QCCKESF 850
                                                ||.||.| ....|..:|     :|.::..
Mouse   294 TEMHEQLGSAEAAGAEGSWPAPSGSPDAGSWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSRKPL 358

  Fly   851 YVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRT---PDTFQTFHAHFIEEYRKMGLMNGMRP-- 910
            :|:||.||||||||||..|.|.:|.|.|....|:   |    |.|| .|:.     |||.|.|
Mouse   359 HVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEP----TNHA-IIQT-----LMNSMDPGS 413

  Fly   911 ----CCAPIKFSSMSLIYY-GDDGIIKRDLPKMVVDECGC 945
                ||.|.|.:.:|::|. ..:.::.:....|||:.|||
Mouse   414 TPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	41/116 (35%)
Gdf6	NP_038554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..93		12/70 (17%)
		TGFb_propeptide	75..284	CDD:279078	39/260 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..268		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..350		7/46 (15%)
		TGF_beta	352..453	CDD:278448	40/110 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810