DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actbeta and Tgfb1

DIOPT Version :9

Sequence 1:NP_651942.2 Gene:Actbeta / 43826 FlyBaseID:FBgn0024913 Length:946 Species:Drosophila melanogaster
Sequence 2:NP_035707.1 Gene:Tgfb1 / 21803 MGIID:98725 Length:390 Species:Mus musculus


Alignment Length:419 Identity:97/419 - (23%)
Similarity:137/419 - (32%) Gaps:150/419 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   566 NKTHTGKNGEMSHNDYEYFNDY------SVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHES 624
            |.|.....||.:..:.|...||      .|...|:|                |..||..|     
Mouse    82 NSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRN----------------NAIYEKTK----- 125

  Fly   625 FADDHENIDHEDF-FGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKP 688
                  :|.|..: |.||.:|                     ...||...|..|:          
Mouse   126 ------DISHSIYMFFNTSDI---------------------REAVPEPPLLSRA---------- 153

  Fly   689 HSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVF---QLSTSINITEKGIDKAIIFRASFQV 750
             .|.:::.||..|:| :...:|:..|.       |.:   :|.|..:..|               
Mouse   154 -ELRLQRLKSSVEQH-VELYQKYSNNS-------WRYLGNRLLTPTDTPE--------------- 194

  Fly   751 DPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTS--------------KL 801
                  |..||:|..:|:|.......:          |.|:|.|....|              |.
Mouse   195 ------WLSFDVTGVVRQWLNQGDGIQ----------GFRFSAHCSCDSKDNKLHVEINGISPKR 243

  Fly   802 RGNSSDYLST--NPNRPFLVL---------HTESSRTRRVRRRAVD---CGGALNGQCCKESFYV 852
            ||:    |.|  :.|||||:|         |..|||    .|||:|   |..:....||....|:
Mouse   244 RGD----LGTIHDMNRPFLLLMATPLERAQHLHSSR----HRRALDTNYCFSSTEKNCCVRQLYI 300

  Fly   853 SF-KALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIK 916
            .| |.||| .||..|:||.||:|.|.|...:    :..|.::..:..|.:........|||.|..
Mouse   301 DFRKDLGW-KWIHEPKGYHANFCLGPCPYIW----SLDTQYSKVLALYNQHNPGASASPCCVPQA 360

  Fly   917 FSSMSLIYYGDDGIIKRDLPKMVVDECGC 945
            ...:.::||.........|..|:|..|.|
Mouse   361 LEPLPIVYYVGRKPKVEQLSNMIVRSCKC 389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ActbetaNP_651942.2 TGFb_propeptide 370..>509 CDD:279078
TGF_beta 843..945 CDD:278448 30/102 (29%)
Tgfb1NP_035707.1 TGFb_propeptide 30..261 CDD:366248 56/280 (20%)
Straightjacket domain. /evidence=ECO:0000250|UniProtKB:P07200 30..74
Arm domain. /evidence=ECO:0000250|UniProtKB:P07200 75..271 57/290 (20%)
Bowtie tail. /evidence=ECO:0000250|UniProtKB:P01137 226..252 6/29 (21%)
Cell attachment site. /evidence=ECO:0000255 244..246 1/1 (100%)
TGF_beta_TGFB1 292..390 CDD:381654 31/103 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11848
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.870

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