DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and unc-129

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_501566.1	Gene:	unc-129 / 177719	WormBaseID:	WBGene00006852	Length:	407	Species:	Caenorhabditis elegans

Alignment Length:	393	Identity:	84/393 - (21%)
Similarity:	145/393 - (36%)	Gaps:	104/393 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   616 ENQKGHHESFADDHENIDHEDFFGNT-------------QEIITFAEEGTQYRQYRI---LEFSA 664
            |:.|..:|:|.|:..|.|     ||.             ||::.|..||....:..:   |.|..
Worm    55 EHMKNLYENFIDEDSNED-----GNLVRAIEPAVGKFEGQEVLVFDVEGFDSHESIMRAELHFYL 114

  Fly   665 QNR----RVPSQKLSIRSAQIH----------IRIDKPHSL------WIEKAKSLPEKHLLNTKR 709
            :.|    |..|:::..:|..::          ||:....:|      | :..||:.:.:.|:.|:
Worm   115 RRRDSFARRRSRQIRAKSVCVNEYCRQQTLKKIRVGGDENLEEYKVIW-DATKSVFDSYHLDAKQ 178

  Fly   710 K-WGANKPHHRIKIWVFQLSTS---------INITEKGIDKAIIFRASFQVDPK--NLGWQKFDL 762
            . :...:.|.:::.:...:..|         :|.|   :|...:.:.:.|...|  :||
Worm   179 AVFRITREHSKMRPYAEMIRKSTPFLVIYSKVNHT---LDTVSVMKQTEQTKRKRRDLG------ 234

  Fly   763 TDTIREWYGHTS-------HEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVL 820
            .:.:||:|.:.|       .|.::.                :..|....|.:..|.:..:.|
Worm   235 NEELREYYNYNSIPLDNDDREPIKR----------------KNGKKNSLSEEISSEDVWQGF--- 280

  Fly   821 HTESSRTRRVR----RRAVDCGGAL---NGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDC 878
            ..|:||..|.|    ..|.|....|   ..:|.||...||.|..|||.::|.|:....::|:|.|
Worm   281 GEETSREERERIANEELANDVRVVLLQNKNRCHKEGVLVSLKHFGWDRYVIEPKTIETSFCKGKC 345

  Fly   879 TGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDG-IIKRDLPKMVVDE 942
            .....|...... ||..      ..|......||||....|::..|..:.| .:.|:..||::..
Worm   346 AKPMLTSGKASN-HAML------QSLFAAEPVCCAPTNLKSLNFWYRDEKGRTVIRNYSKMLIGS 403

  Fly   943 CGC 945
            |.|
Worm   404 CSC 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	29/102 (28%)
unc-129	NP_501566.1	TGFB	312..406	CDD:214556	29/100 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810