DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and daf-7

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_497265.1	Gene:	daf-7 / 175237	WormBaseID:	WBGene00000903	Length:	350	Species:	Caenorhabditis elegans

Alignment Length:	343	Identity:	80/343 - (23%)
Similarity:	132/343 - (38%)	Gaps:	81/343 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 TQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPH--SLWIEKAKSLPEK---------HLL 705
            |:|.:..||:           :|:::.|...::...|.  |:::|..:.|.||         ...
Worm    39 TEYLKNEILD-----------QLNMKEAPKGLKPMDPEMKSVYLEMYRDLLEKDEQDMGVEMSFY 92

  Fly   706 NTK------------RKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKN---- 754
            ..|            .|:.......|..|....|:.||.|..|  |..::.....||..||
Worm    93 TAKDPSYGENPSQLVAKFDVTNDLERSDILQATLTVSIEIPAK--DSGMLQDVQVQVYEKNEDGS 155

  Fly   755 ------------LGWQKFDL---TDTIREWYGHTSHEKL--RLLIDCTGCGGRYSLHLFQTSKLR 802
                        .|.::..:   .||::.|:..:..:.:  :.::|    |...:||..||:...
Worm   156 MGEMVTSGIFATKGSERISIQLPIDTVKSWFTISPIQGIFVKAMLD----GRNVALHPQQTTADV 216

  Fly   803 GNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPR 867
            .|....|||.|         :.||.||...:.|....|.:..||.....:.|:.:|| |||:||.
Worm   217 DNMRLQLSTRP---------KGSRKRRSHAKPVCNAEAQSKGCCLYDLEIEFEKIGW-DWIVAPP 271

  Fly   868 GYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRP----CCAPIKFSSMSLIYYGDD 928
            .|.|..|||||..:....:..:|.|:..:....|:.     .|    ||.|.::..:.|||...|
Worm   272 RYNAYMCRGDCHYNAHHFNLAETGHSKIMRAAHKVS-----NPEIGYCCHPTEYDYIKLIYVNRD 331

  Fly   929 GIIK-RDLPKMVVDECGC 945
            |.:. .::..|:..:|||
Worm   332 GRVSIANVNGMIAKKCGC 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	31/106 (29%)
daf-7	NP_497265.1	TGFB	250..350	CDD:214556	33/106 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770