DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Gdf9

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_032136.2	Gene:	Gdf9 / 14566	MGIID:	95692	Length:	441	Species:	Mus musculus

Alignment Length:	371	Identity:	83/371 - (22%)
Similarity:	141/371 - (38%)	Gaps:	94/371 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   641 TQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLS--IRSAQIHIRIDKPHSLWIEKAKSLPEKH 703
            |:|.:........|...|:....||..:.||.:::  :....:...:|:..::          :|
Mouse    98 TKEGVPKPSRSHLYNTVRLFSPCAQQEQAPSNQVTGPLPMVDLLFNLDRVTAM----------EH 152

  Fly   704 LLNTKRKWGANKPHHRIKIWVFQLSTSINIT---EKGIDKAIIF-----RASFQVDPKNLGWQKF 760
            ||.:...:..|.          ..|:|..:|   :..:.:|:..     ||.:....|...|.:.
Mouse   153 LLKSVLLYTLNN----------SASSSSTVTCMCDLVVKEAMSSGRAPPRAPYSFTLKKHRWIEI 207

  Fly   761 DLTDTIREWYGHTSHEK-LRLLIDCTGC-------GGRYS----------LHLFQTSKLRGNSSD 807
            |:|..::...  ||.|: :.|.::.| |       .|.:|          |:|..||....:|..
Mouse   208 DVTSLLQPLV--TSSERSIHLSVNFT-CTKDQVPEDGVFSMPLSVPPSLILYLNDTSTQAYHSWQ 269

  Fly   808 YLST------NPN------RPFL--VLHTESSRTRRVRRRAV--DCGGAL--------------- 841
            .|.:      :|.      ||..  .:..|.|..||..::|:  :..|.|
Mouse   270 SLQSTWRPLQHPGQAGVAARPVKEEAIEVERSPRRRRGQKAIRSEAKGPLLTASFNLSEYFKQFL 334

  Fly   842 --NGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFR----TPDTFQTFHAHFIEEYR 900
              ..:|....|.:||..|.||:||:||..|...||:|||..:.|    :|  ..|...:.|  |.
Mouse   335 FPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYGSP--VHTMVQNII--YE 395

  Fly   901 KMGLMNGMRPCCAPIKFSSMSLIYYGDDG-IIKRDLPKMVVDECGC 945
            |:. .:..||.|.|.|:|.:|::....|| |..::...|:...|.|
Mouse   396 KLD-PSVPRPSCVPGKYSPLSVLTIEPDGSIAYKEYEDMIATRCTC 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	35/106 (33%)
Gdf9	NP_032136.2	TGF_beta_GDF9	336..441	CDD:381673	36/110 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810