DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and admp

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_571951.2	Gene:	admp / 140619	ZFINID:	ZDB-GENE-011214-1	Length:	391	Species:	Danio rerio

Alignment Length:	307	Identity:	82/307 - (26%)
Similarity:	129/307 - (42%)	Gaps:	62/307 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   686 DKPHSLWIE-------KAKS----LPEKHLLNTKRKWG--ANKPHHRIKIWVFQLSTSINITEKG 737
            ||.||..||       .|||    ..|.||...:.|..  .|: ||..::.|:|:   ::.::|.
Zfish    99 DKLHSERIEYLFNMSTVAKSEKILTAELHLFKLRPKTSIVLNR-HHFCQVSVYQV---LDSSKKN 159

  Fly   738 IDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDC-TGCGGRYSLHLFQTSKL 801
            :.:.....:|..|...:.||:.|.:|..:|.|..... ..|.||:.. |..|.:..|.:.:.:..
Zfish   160 VSQGKKLLSSRLVPIHSTGWEVFTITQAVRSWMSDEG-SNLGLLVSVRTLAGSQMDLKMVRFASG 223

  Fly   802 RGNSSDYLSTNPNRPFLVLHTESSR---------------------------TRRVRRRAVDCGG 839
            |.:.      :..:|.|||.|:..|                           ..|...|:||...
Zfish   224 RDHH------HSKQPMLVLFTDDGRRAASLEATSKGSDVSPGGSSQPLPSVPASRRSSRSVDYDE 282

  Fly   840 ALNGQ---CCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQ-TFHAHFIEEYR 900
              .|:   |.::..||.|:.:||..||::|:||.|.:|:|.|.  |......: |.||.......
Zfish   283 --RGEKMACQRQPLYVDFEEIGWSGWIVSPKGYNAYHCKGSCI--FPLSQNMRPTNHAIVQSIIN 343

  Fly   901 KMGLMNGMR-PCCAPIKFSSMSLIYYGDD-GIIKRDLPKMVVDECGC 945
            .:.|..|:: |||.|.|..|:||:|:.|| .::.:....||...|||
Zfish   344 TLKLNKGIQTPCCVPDKLYSISLLYFDDDENVVLKQYDDMVAGSCGC 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	36/107 (34%)
admp	NP_571951.2	TGFb_propeptide	40..237	CDD:279078	37/148 (25%)
admp	NP_571951.2	TGFB	289..391	CDD:214556	37/104 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810