Protein Alignment Actbeta and Gdf2

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_062379.3
• Gene: Gdf2 / 12165
• MGIID: 1321394
• Length: 428
• Species: Mus musculus
• Alignment Length: 252
• Identity: 61/252 - (24%)
• Similarity: 93/252 - (36%)
• Gaps: 76/252 - (30%)

  Fly   751 DPKNLGWQKFDLTDTIREWY---GHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTN 812
            |.::.||:..:::..::.|.   ..|:..||.:.:.    ..|.|......|...|:.
Mouse   195 DIRDEGWETLEVSSAVKRWVRADSTTNKNKLEVTVQ----SHRESCDTLDISVPPGSK------- 248

  Fly   813 PNRPFLVL---------------------HTESSRTRRVRRRAVDCGG------ALNG------- 843
             |.||.|:                     |.:.:...:..:.|....|      .|:|
Mouse   249 -NLPFFVVFSNDRSNGTKETRLELKEMIGHEQETMLVKTAKNAYQVAGESQEEEGLDGYTAVGPL 312

  Fly   844 ------------QCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHA--- 893
                        .|.|.|..|:|:.:|||.|||||:.|.|..|:|.|.... ..|...|.||
Mouse   313 LARRKRSTGASSHCQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFPL-ADDVTPTKHAIVQ 376

  Fly   894 ---HFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGI--IKRDLPKMVVDECGC 945
               | ::...|:|     :.||.|.|.|.:|::|..|.|:  :|.....|.|.||||
Mouse   377 TLVH-LKFPTKVG-----KACCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGC 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	39/107 (36%)
Gdf2	NP_062379.3	TGFb_propeptide	69..215	CDD:480997	4/19 (21%)
		TGF_beta_BMP9	324..428	CDD:381670	41/111 (37%)
		Interaction with ENG. /evidence=ECO:0000250|UniProtKB:Q9UK05	401..415		4/13 (31%)