DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp8b

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_031585.2	Gene:	Bmp8b / 12164	MGIID:	107335	Length:	399	Species:	Mus musculus

Alignment Length:	368	Identity:	86/368 - (23%)
Similarity:	141/368 - (38%)	Gaps:	93/368 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 HESFADD------HENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQ 680
            :.:..||      ..::|..|...:...|:. .:....|::....||.....::|:.: ::.:|:
Mouse    80 YRAMTDDSGGGTPQPHLDRADLIMSFVNIVE-RDRTLGYQEPHWKEFHFDLTQIPAGE-AVTAAE 142

  Fly   681 IHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFR 745
            ..|..:             |..|.|||           .:.|.:|::....:..|..:
Mouse   143 FRIYKE-------------PSTHPLNT-----------TLHISMFEVVQEHSNRESDL------- 176

  Fly   746 ASFQVDPKNL-----GWQKFDLTDTIREWYGHTSHEK---LRLLID----------CTGCGGRY- 791
              |.:|.:.|     ||...|:|.....|.  .:|.|   |||.::          ..|..||.
Mouse   177 --FFLDLQTLRSGDEGWLVLDITAASDRWL--LNHHKDLGLRLYVETEDGHSIDPGLAGLLGRQA 237

  Fly   792 --SLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRR--------RAVDCGGALNGQ-- 844
              |...|.....|.|.|...:....||.     :..:..::.:        ..:|.|...:|:
Mouse   238 PRSRQPFMVGFFRANQSPVRAPRTARPL-----KKKQLNQINQLPHSNKHLGILDDGHGSHGREV 297

  Fly   845 CCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMR 909
            |.:...||||:.|||.|.:|||:||.|.||.|:|.....:... .|.||      ....|::.|:
Mouse   298 CRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYPLNSCMN-STNHA------TMQALVHLMK 355

  Fly   910 P------CCAPIKFSSMSLIYYG-DDGIIKRDLPKMVVDECGC 945
            |      ||.|.:.|::||:||. ::.:|.|....|||..|||
Mouse   356 PDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMVVQACGC 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	40/110 (36%)
Bmp8b	NP_031585.2	TGFb_propeptide	32..248	CDD:279078	37/204 (18%)
Bmp8b	NP_031585.2	TGF_beta	298..398	CDD:278448	39/106 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810