DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp8a

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001242948.1	Gene:	Bmp8a / 12163	MGIID:	104515	Length:	412	Species:	Mus musculus

Alignment Length:	387	Identity:	86/387 - (22%)
Similarity:	142/387 - (36%)	Gaps:	118/387 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 HESFADDHENIDHEDFFGNTQEIITFA-----EEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQI 681
            :.:..||.:....:...|....:::|.     :....|::....||.....::|:.: ::.:|:.
Mouse    80 YHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGE-AVTAAEF 143

  Fly   682 HIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRA 746
            .|..:             |..|.|||           .:.|.:|::....:..|..:
Mouse   144 RIYKE-------------PSTHPLNT-----------TLHISMFEVVQEHSNRESDL-------- 176

  Fly   747 SFQVDPKNL-----GWQKFDLTDTIREWYGHTSHEK---LRLLIDCTGCGGRYSLHLFQTSKLRG 803
             |.:|.:.|     ||...|:|.....|.  .:|.|   |||.::...                |
Mouse   177 -FFLDLQTLRSGDEGWLVLDITAASDRWL--LNHHKDLGLRLYVETAD----------------G 222

  Fly   804 NSSD--------YLSTNPNRPFLVLHTESSRT--------RRVRRR----------------AVD 836
            :|.|        ..:....:||:|....:|::        |.::||                ..|
Mouse   223 HSMDPGLAGLLGRQAPRSRQPFMVTFFRASQSPVRAPRAARPLKRRQPKKTNELPHPNKLPGIFD 287

  Fly   837 CGGALNGQ--CCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFI--- 896
            .|....|:  |.:...||||:.|||.||:|||:||.|.||.|:|....   |:......|.|
Mouse   288 DGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFPL---DSCMNATNHAILQS 349

  Fly   897 ---------EEYRKMGLMNG---MRPCCAPIKFSSMSLIYY-GDDGIIKRDLPKMVVDECGC 945
                     :.:..:.||..   .:.||||.|.|:.|::|| ..:.:|.|....|||..|||
Mouse   350 LVSTTVACCDRWSGVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	41/119 (34%)
Bmp8a	NP_001242948.1	TGFb_propeptide	32..248	CDD:279078	37/219 (17%)
Bmp8a	NP_001242948.1	TGF_beta	298..411	CDD:278448	40/115 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810