Protein Alignment Actbeta and Bmp6

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_031582.1
• Gene: Bmp6 / 12161
• MGIID: 88182
• Length: 510
• Species: Mus musculus
• Alignment Length: 635
• Identity: 132/635 - (20%)
• Similarity: 207/635 - (32%)
• Gaps: 264/635 - (41%)

  Fly   374 IKRQILTKLGLSHKPNVSHPL---------PKQFIWETIYRVDGGRMIPNNAFGSSGKNLDQKTI 429
            ::::||:.|||.|:|...|.|         |:|                      ..:...|:|
Mouse    76 MQKEILSVLGLPHRPRPLHGLQQPQPPVLPPQQ----------------------QQQQQQQQT- 117

  Fly   430 KLRAFASPGSHLFNGRGGRTDQRSERDPSHHKYRSPFDFTFNISKNNVYGKVLRNRSLERIDKKN 494
                                 .|.|..|..                      |::..|..:|..|
Mouse   118 ---------------------AREEPPPGR----------------------LKSAPLFMLDLYN 139

  Fly   495 SFLNGWTENRQLKINSQIASMPIELKSHHNSSPKELKS---GAVRKVNGINGTQMNENALKKSTY 556
            :..|...|:...:...|      |..||..:|..:|:.   ||.
Mouse   140 ALSNDDEEDGASEGVGQ------EPGSHGGASSSQLRQPSPGAA--------------------- 177

  Fly   557 PIDINHSIDNKT------HTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEY 615
                 ||::.|:      ..|.:...|..|..:.||..:                ....::.:||
Mouse   178 -----HSLNRKSLLAPGPGGGASPLTSAQDSAFLNDADM----------------VMSFVNLVEY 221

  Fly   616 ENQKGHHESFADDHENIDHEDFFGNTQEI-----ITFAEEGTQYRQYR---ILEFSAQNRRVPSQ 672
            :.:...|:.        .|::|..|..:|     :|.||    :|.|:   :..|..|...:...
Mouse   222 DKEFSPHQR--------HHKEFKFNLSQIPEGEAVTAAE----FRVYKDCVVGSFKNQTFLISIY 274

  Fly   673 KLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKG 737
            ::    .|.|...|.             :..||:|:..|.:.:
Mouse   275 QV----LQEHQHRDS-------------DLFLLDTRVVWASEE---------------------- 300

  Fly   738 IDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEK-LRLLIDCTGCGGRYSLHLF-QTSK 800
                              ||.:||:|.|...|.....|.. |:|.:..     |..||:. :.:.
Mouse   301 ------------------GWLEFDITATSNLWVVTPQHNMGLQLSVVT-----RDGLHVNPRAAG 342

  Fly   801 LRGNSSDYLSTNPNRPFLV-------LHTESSRTRRVRRR------------------AVDCGGA 840
            |.|....|    ..:||:|       :|..::|:...|||                  :.|..|:
Mouse   343 LVGRDGPY----DKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVSRGSGSSDYNGS 403

  Fly   841 -LNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRK--- 901
             |...|.|...||||:.|||.||||||:||.||||.|:|  ||       ..:||.......
Mouse   404 ELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGEC--SF-------PLNAHMNATNHAIVQ 459

  Fly   902 --MGLMNG---MRPCCAPIKFSSMSLIYYGDD-GIIKRDLPKMVVDECGC 945
              :.|||.   .:|||||.|.:::|::|:.|: .:|.:....|||..|||
Mouse   460 TLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	44/108 (41%)
Bmp6	NP_031582.1	TGFb_propeptide	58..359	CDD:459906	78/474 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..129		12/107 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..199		14/87 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..402		5/31 (16%)
		TGF_beta_BMP6	408..510	CDD:381666	46/111 (41%)