Protein Alignment Actbeta and Bmp5

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_031581.2
• Gene: Bmp5 / 12160
• MGIID: 88181
• Length: 454
• Species: Mus musculus
• Alignment Length: 538
• Identity: 117/538 - (21%)
• Similarity: 188/538 - (34%)
• Gaps: 177/538 - (32%)

  Fly   472 ISKNNVYG----KVLRNRSLERIDKKNSFLNGWTEN-RQLKINSQIASMPIELKSHHNSSPKELK 531
            :..|:|:.    :.|||.....|.::...:.|.... |......|.:|.|:.:...:|:
Mouse    29 LGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNA------ 87

  Fly   532 SGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQT----- 591
                         ..:|:..::|.|.:.::.:.:.| .|.|....|.|.|.:......:|
Mouse    88 -------------MASEDNPEESEYLVRVSLAGEAK-ETRKGYPASPNGYAHRLHLPPRTPLTTQ 138

  Fly   592 -------HDKNRYHEGRSSIGYQPAI-HNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFA 648
                   ||.|..::....:.:...: .:.::.:|:.|::.|..|...|.|       .|.:|.|
Mouse   139 SPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPH-------GEAVTAA 196

  Fly   649 EEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGA 713
            |    :|.|:
Mouse   197 E----FRIYK------------------------------------------------------- 202

  Fly   714 NKPHHR-----IKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHT 773
            :|.:||     |||.::|:..  ..|.:..|..::.....|.  .::||..||:|.|...|..:.
Mouse   203 DKGNHRFENETIKISIYQIIK--EYTNRDADLFLLDTRKTQA--LDVGWLVFDITVTSNHWVINP 263

  Fly   774 SHEKLRLLIDCTGCG-----------GR--------YSLHLFQTSK--LRGNSSDYLSTNPNRPF 817
            .:.....|...||.|           ||        :.:..|:.|:  ||...:.....|.||..
Mouse   264 QNNLGLQLCAETGDGRSINVKSAGLVGRHGPQSKQPFMVAFFKASEVLLRSVRAASKRKNQNRNK 328

  Fly   818 LVLHTESSRTRRVRRRAVDCGGALNGQCCKE-SFYVSFKALGWDDWIIAPRGYFANYCRGDCTGS 881
            ...|.:.||    ...|.|...:...|.||: ..||||:.|||.||||||.||.|.||.|:|  |
Mouse   329 SNSHQDPSR----MPSAGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGEC--S 387

  Fly   882 FRTPDTFQTFHAHFIEEYRKMGLMNGM------------------RPCCAPIKFSSMSLIYYGD- 927
            |       ..:||          ||..                  :|||||.|.:::|::|:.|
Mouse   388 F-------PLNAH----------MNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDS 435

  Fly   928 DGIIKRDLPKMVVDECGC 945
            ..:|.:....|||..|||
Mouse   436 SNVILKKYRNMVVRSCGC 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	42/119 (35%)
Bmp5	NP_031581.2	TGFb_propeptide	32..304	CDD:459906	60/361 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..347		8/32 (25%)
		TGF_beta_BMP5	342..454	CDD:381665	46/131 (35%)