DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp15

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_033887.1	Gene:	Bmp15 / 12155	MGIID:	1316745	Length:	392	Species:	Mus musculus

Alignment Length:	379	Identity:	99/379 - (26%)
Similarity:	145/379 - (38%)	Gaps:	109/379 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 KGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVP------------- 670
            |.:|.| ||.|         |:.:|..|...     :..|:::.||...|.|
Mouse    70 KLYHRS-ADPH---------GHPRENRTIGA-----KMVRLVKPSANTVRPPRGSWHVQTLDFPL 119

  Fly   671 -SQKLS---IRSA-----QIHI---RIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIW 723
             |.:::   ||:.     |:|:   .:......|:.|.::   |||.::|.  |::||....|.|
Mouse   120 ASNQVAYELIRATVVYRHQLHLVNYHLSCHVETWVPKCRT---KHLPSSKS--GSSKPSPMSKAW 179

  Fly   724 VFQLSTSINIT---------EKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLR 779
                 |.|:||         .||   ..:.|..|....     ||.:.|...| |:|.||.:...
Mouse   180 -----TEIDITHCIQQKLWNRKG---RSVLRLRFMCQQ-----QKGNETREFR-WHGMTSLDVAF 230

  Fly   780 LLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRA------VDC- 837
            ||:.......|..      .||.....:.|:..          |||...|..|:|      ..|
Mouse   231 LLLYFNDTDDRVQ------GKLLARGQEELTDR----------ESSFLMRSVRQACSIESDASCP 279

  Fly   838 ----GGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTG----SFRTPDTFQTFHAH 894
                .|::|.||....:.|||..||||.||||||.|..|||:|.||.    ...:|:       |
Mouse   280 SQEHDGSVNNQCSLHPYKVSFHQLGWDHWIIAPRLYTPNYCKGICTRVLPYGLNSPN-------H 337

  Fly   895 FIEEYRKMGLMNGM--RPCCAPIKFSSMSLIYYGDDG-IIKRDLPKMVVDECGC 945
            .|.:.....|:|..  :|.|.|..|..||::....:| |:.::...|:...|.|
Mouse   338 AIIQSLVNELVNHSVPQPSCVPYNFLPMSILLIETNGSILYKEYEGMIAQSCTC 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	37/108 (34%)
Bmp15	NP_033887.1	TGF_beta	289..391	CDD:278448	37/108 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810