DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and Bmp3

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001297606.1	Gene:	Bmp3 / 110075	MGIID:	88179	Length:	470	Species:	Mus musculus

Alignment Length:	368	Identity:	73/368 - (19%)
Similarity:	121/368 - (32%)	Gaps:	135/368 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 GNTQEIITFAEEGT-QYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPE- 701
            |||......|..|| |.:.......::.     ::..:|.||.::..:.:    .:..:.|.||
Mouse    92 GNTVRSFRAAAAGTPQTKGLHTFNLTSL-----TKSENILSATLYFYVGE----LVNISLSCPEP 147

  Fly   702 ---KHLLNTKRKWGANKPHHRIKI--WVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFD 761
               .|  :|:|:      |.:|.:  |:.:.:.|..:....:|....:|.|       :.|...|
Mouse   148 QGCSH--HTQRQ------HIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDS-------VSWLSKD 197

  Fly   762 LTDTIRE---------WYGHTS--HEKLRLLI------------------------------DCT 785
            :|..:|:         .:..||  ||..:.::                              |.|
Mouse   198 ITQLLRKAKQNEEFLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDFT 262

  Fly   786 -GCGGRYSLHL-------------------FQTSKLRGNSSDYL---STNPNRPFLVLHT---ES 824
             |.|.|...|:                   .|.::|.|....|.   :....:|:..|.|   |.
Mouse   263 AGTGPRLDSHVREALSVERRKKRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQPPEK 327

  Fly   825 SRTRRVRRRAVDCGGALNGQ----------------------CCKESFYVSFKALGWDDWIIAPR 867
            ||.::.:|:    |....||                      |.:....|.|..:||.:|||:|:
Mouse   328 SRNKKKQRK----GSHQKGQTLQFDEQTLKKARRKQWVEPRNCARRYLKVDFADIGWSEWIISPK 388

  Fly   868 GYFANYCRGDCTGSFRTPDTFQTFHA---------HFIEEYRK 901
            .:.|.||.|.|  .|..|.......|         |.:|||.|
Mouse   389 SFDAFYCSGAC--QFPMPKVAAAAAALHLVLISFLHGVEEYAK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	24/90 (27%)
Bmp3	NP_001297606.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..53
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..349		10/38 (26%)
		TGF_beta	364..>424	CDD:278448	18/61 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910