Protein Alignment Actbeta and GDF11

DIOPT Version :10

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 121/617 - (19%)
• Similarity: 182/617 - (29%)
• Gaps: 281/617 - (45%)

  Fly   354 KKTNQPHNNIAP-------------SDEVRLESIKRQILTKLGLSHKPNVSHPLPKQFIWET--- 402
            :::::|..::||             |.|:||||||.|||:||.|...||:|..:.||.:.:.
Human    46 ERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPL 110

  Fly   403 -----IYRVDGGRMIPNNAFGSSGKNLDQKTIKLRAFASPGSHLFNGRGGRTDQRSERDPSHHKY 462
                 ::...|..:.|.:.......:...:|:                   .....|.||:....
Human   111 QQILDLHDFQGDALQPEDFLEEDEYHATTETV-------------------ISMAQETDPAVQTD 156

  Fly   463 RSPFDFTFNISKNNVYGKVLRNRSLERIDKKNSFLNGWTENRQLKINSQIASMPIELKSHHNSSP 527
            .||....|:.|...::.|||:.:.             |...|.:...:.:....:.||
Human   157 GSPLCCHFHFSPKVMFTKVLKAQL-------------WVYLRPVPRPATVYLQILRLK------- 201

  Fly   528 KELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTH 592
                                         |:     ....|..|..|
Human   202 -----------------------------PL-----TGEGTAGGGGG------------------ 214

  Fly   593 DKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQY 657
                   ||..|..:..  .||..::.||.:|.          ||    ::::
Human   215 -------GRRHIRIRSL--KIELHSRSGHWQSI----------DF----KQVL------------ 244

  Fly   658 RILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKI 722
                                           || |..:.:|           .||       |:|
Human   245 -------------------------------HS-WFRQPQS-----------NWG-------IEI 259

  Fly   723 WVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGC 787
            ..|..|        |.|.|:                                          |..
Human   260 NAFDPS--------GTDLAV------------------------------------------TSL 274

  Fly   788 G-GRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCG-GALNGQCCKESF 850
            | |...||                     ||:.|....:..|..|...:||. .:...:||:...
Human   275 GPGAEGLH---------------------PFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPL 318

  Fly   851 YVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTF-HAHFIEEYRKMGLMNGMRPCCAP 914
            .|.|:|.|| ||||||:.|.||||.|.|...|     .|.: |.|.:::....|   ...|||.|
Human   319 TVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF-----MQKYPHTHLVQQANPRG---SAGPCCTP 374

  Fly   915 IKFSSMSLIYYGD-DGIIKRDLPKMVVDECGC 945
            .|.|.::::|:.| ..||...:|.||||.|||
Human   375 TKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	41/101 (41%)
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:480997	69/470 (15%)
		TGF_beta_GDF8	301..407	CDD:381658	45/115 (39%)