DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and bmp5

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_004914553.1	Gene:	bmp5 / 100494976	XenbaseID:	XB-GENE-479371	Length:	449	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	116/543 - (21%)
Similarity:	190/543 - (34%)	Gaps:	173/543 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 PSHHKYRSPFDFTFNISKNNVYGKVLRNRSLERIDKKNSFLNGWTEN-RQLKINSQIASMPIELK 520
            |.:|.:.|   |.:         :.|||...:.|.::...:.|.... |......|.:|.|:.:.
Frog    25 PGNHVHSS---FIY---------RRLRNHERKEIQREILSILGLPHRPRPFSPGKQASSAPLFML 77

  Fly   521 SHHNSSPKELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEM--------S 577
            ..:|:..||.....:...  ::|..:....|:|. ||: :.:....|....:|..:        |
Frog    78 DLYNAMAKEDDHSMLGYT--LSGAMLESRGLRKG-YPV-VANGYSRKAQAYRNAPLTTQRPPLAS 138

  Fly   578 HNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQ 642
            ..|..:.||..:.....|.....:            ::.:.:.|::.|..|...|.|       .
Frog   139 LQDSNFLNDADMVMSFVNLVERDK------------DFSHNRRHYKEFRFDLTQIPH-------G 184

  Fly   643 EIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNT 707
            |.:|.||    :|.|:    ...|.|..::.|.|...|| |:         :.:....:..||:|
Frog   185 EAVTAAE----FRIYK----DRSNNRFGNETLKISIYQI-IK---------DYSNRDADLFLLDT 231

  Fly   708 KRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGH 772
            :|                                        |...::||..||:|.|...|..:
Frog   232 QR----------------------------------------VQTYDVGWLVFDITVTSNHWVIN 256

  Fly   773 TSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLH-------------TES 824
            ..:.....|...|..|...|:   :::.|.|..    .....:||||..             |.:
Frog   257 PQNNLGLQLCAETSDGRSVSV---KSAGLIGRH----GPQSKQPFLVAFFKASEVLLRSVRATNT 314

  Fly   825 SRTRRVRRRAV------------DCGGALNGQCCKE-SFYVSFKALGWDDWIIAPRGYFANYCRG 876
            .:.::.|.::.            |...:...|.||: ..||||:.|||:||||||.||.|.||.|
Frog   315 KKKKQDRNKSTTSHDASRMPSIGDYNTSEQKQACKKHELYVSFRDLGWEDWIIAPEGYAAFYCDG 379

  Fly   877 DCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGM------------------RPCCAPIKFSSMSLI 923
            :|  ||       ..:||          ||..                  :|||||.|.:::|::
Frog   380 EC--SF-------PLNAH----------MNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVL 425

  Fly   924 YYGD-DGIIKRDLPKMVVDECGC 945
            |:.| ..:|.:....|||..|||
Frog   426 YFDDSSNVILKKYRNMVVRSCGC 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078	10/52 (19%)
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	43/121 (36%)
bmp5	XP_004914553.1	TGFb_propeptide	27..298	CDD:366248	67/370 (18%)
bmp5	XP_004914553.1	TGF_beta_BMP5	337..449	CDD:381665	46/131 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910