DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and inhbc.2

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_002939474.1	Gene:	inhbc.2 / 100494560	XenbaseID:	XB-GENE-1217521	Length:	354	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	84/328 - (25%)
Similarity:	132/328 - (40%)	Gaps:	75/328 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   635 EDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSL 699
            ||...:.::    |||....:.|.::.|:    .:.|.:.|......|:..:|
Frog    84 EDLLSSREQ----AEELDSDQDYEVISFA----DIESSQASQTILHFHLSAEK------------ 128

  Fly   700 PEKHLLNTKRKWGANKPHHRIKIWVF-----------QLSTSINITEKGIDKAI---IFRASFQV 750
                        |..:..|...:|::           |::||: ..||...:.|   |.|:
Frog   129 ------------GTYREIHNAALWLYLQSDPSKKLAIQITTSL-AKEKSSTEMIHREIVRS---- 176

  Fly   751 DPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNR 815
                 ||....|....:...| ...|.:.|.::|..|.|:..:.         |.||     ..|
Frog   177 -----GWYTLPLPMLTQAALG-DGEENIYLYLECLNCTGQPVIR---------NISD-----AQR 221

  Fly   816 PFLVLHTESSR-TRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCT 879
            ||||:...:.| ..|.||...:|...:: .||:::||:.||.:||.||||:|.||..|||.|.|.
Frog   222 PFLVVKAHNQREDHRFRRHITECSSDVD-MCCRKNFYIDFKEIGWTDWIISPEGYNMNYCEGRCP 285

  Fly   880 GSF-RTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYG-DDGIIKRDLPKMVVDE 942
            ... |.|....:.|...:...:...|......||.|.|...:||:|:. .:.|:|.|:|.|:|:.
Frog   286 VHLARVPGIAASSHTAILSLIKANNLYASFSSCCVPTKRRPLSLLYFDMYNSIVKTDIPDMIVES 350

  Fly   943 CGC 945
            |||
Frog   351 CGC 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	38/103 (37%)
inhbc.2	XP_002939474.1	TGFb_propeptide	50..226	CDD:366248	38/198 (19%)
inhbc.2	XP_002939474.1	TGF_beta_SF	251..354	CDD:394804	40/103 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5766
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm48117
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070